<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">OJOph</journal-id><journal-title-group><journal-title>Open Journal of Ophthalmology</journal-title></journal-title-group><issn pub-type="epub">2165-7408</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/ojoph.2023.134032</article-id><article-id pub-id-type="publisher-id">OJOph-128956</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Epidemiological and Diagnostic Aspects of Childhood Proptosis in Lome (Togo) from 2010 to 2020
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Nidain</surname><given-names>Maneh</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Mawuli</surname><given-names>Ayodele Komi Santos</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Koffi</surname><given-names>Sylvain Kawilitetou</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Dadjo</surname><given-names>Amouzou</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kossi</surname><given-names>Dzidzinyo</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kokou</surname><given-names>Vonor</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Didier</surname><given-names>Koffi Ayena</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Patrice</surname><given-names>Komi Balo</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff2"><addr-line>Ophthalmology Department of CHP-Aneho, University of Lome, Aneho, Togo</addr-line></aff><aff id="aff4"><addr-line>Ophthalmology Department CHR-Tomde, University of Kara, Kara, Togo</addr-line></aff><aff id="aff3"><addr-line>Ophthalmology Department of CHU Sylvanus Olympio, University of Lome, Lome, Togo</addr-line></aff><aff id="aff1"><addr-line>Ophthalmology Department of CHU-Campus, University of Lome, Lome, Togo</addr-line></aff><pub-date pub-type="epub"><day>08</day><month>11</month><year>2023</year></pub-date><volume>13</volume><issue>04</issue><fpage>333</fpage><lpage>340</lpage><history><date date-type="received"><day>10,</day>	<month>September</month>	<year>2023</year></date><date date-type="rev-recd"><day>6,</day>	<month>November</month>	<year>2023</year>	</date><date date-type="accepted"><day>9,</day>	<month>November</month>	<year>2023</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
   <b>Background:</b> Although proptosis is rare, it is nevertheless the main sign of orbital disease. Its discovery usually indicates a serious eye disease especially in children. <b>Objective: </b>To determine epidemiological and diagnostic aspects of childhood proptosis in Lome (Togo). <b>Methods:</b> Retrospective cross-sectional study conducted from June 2010 to May 2020, which is 10 years, in the ophthalmology department of CHU-campus of Lome. Files of patients between the age of 0 and 15 who presented a proptosis during the study period were taken into account in the study. Patients with a false proptosis or incomplete records during the study period were not taken into account in the study. <b>Results: </b>The study<b> </b>considered 42 children with an age average of 7.63 years &#177; 4.96 [4 days; 15 years] and a sex-ratio of 1.33. The frequency of proptosis was 0.5% with an average progression of 383.7 days before the first consultation. The proptosis was unilateral in 80.95% of cases. The orbito-cerebral CT scan was done in 47.62% of cases. The proptosis in these patients was predominantly of grade 3 in 45% of cases. The tumor pathologies were at the forefront in 35.71%, dominated by retinoblastoma, and followed by infectious and inflammatory diseases in 14.29%. <b>Conclusion:</b> Childhood proptosis is rare and often indicative of infectious and tumor pathologies in our context. Its diagnosis is delayed, which shows the importance of an early and effective diagnosis. 
 
</p></abstract><kwd-group><kwd>Childhood Proptosis</kwd><kwd> Tumors</kwd><kwd> Infections</kwd><kwd> Lome</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Proptosis is defined as an irregular protrusion of the eyeball [<xref ref-type="bibr" rid="scirp.128956-ref1">1</xref>] . This is the effect of the imbalance between the increase in volume of the content of the eyeball and the other intra orbital structures and the fixity of the orbital container (bony orbit) which irregularly moves the eyeball to a postero-anterior position [<xref ref-type="bibr" rid="scirp.128956-ref2">2</xref>] .</p><p>Although proptosis is rare [<xref ref-type="bibr" rid="scirp.128956-ref3">3</xref>] , it is nevertheless the main sign of orbital disease. Its discovery usually indicates a serious eye disease especially in children [<xref ref-type="bibr" rid="scirp.128956-ref4">4</xref>] , thus requiring an urgent care.</p><p>Causes of proptosis are multiple and diverse. In adults, thyro&#239;d disorders are the most common causes of proptosis [<xref ref-type="bibr" rid="scirp.128956-ref5">5</xref>] . In the other hand, in children, the infectious and or inflammatory disease and the tumors are at the forefront [<xref ref-type="bibr" rid="scirp.128956-ref6">6</xref>] . The literature is, however, disparate on the predominance of one or the other etiological group both in Africa [<xref ref-type="bibr" rid="scirp.128956-ref7">7</xref>] and in the rest of the world.</p><p>In Togo, few studies are devoted to proptosis in children [<xref ref-type="bibr" rid="scirp.128956-ref8">8</xref>] and that justifies the present study, which objective is to establish the epidemiological and diagnostic profiles of proptosis in children at CHU Campus of Lome.</p></sec><sec id="s2"><title>2. Methods</title><sec id="s2_1"><title>2.1. Study Outline</title><p>This presents a cross-sectional and descriptive study conducted on the examination of medical records of children aged 0 to 15 who sought consultation at the ophthalmology department of CH CHU Campus of Lom&#233; from June 1, 2010, through May 31, 2020. Cases of false proptosis or incomplete records were excluded from the analysis. The study aimed to analyze cases of unilateral or bilateral proptosis in children within this ten-year period. The ophthalmology department of CH CHU Campus of Lom&#233;, being the sole center with a dedicated pediatric ophthalmology unit in Togo, played a crucial role in providing data for this study.</p></sec><sec id="s2_2"><title>2.2. Ethics</title><p>Privacy and confidentiality of the data collected were respected with reference to ethical principles established in the declaration of Helsinki.</p></sec><sec id="s2_3"><title>2.3. Operational Definition</title><p>-Proptosis onset: is the time interval between the date of symptom onset and the date of first consultation.</p><p>-Acute proptosis: if the development time of proptosis is less than one month.</p><p>- Subacute proptosis: if the evolution of proptosis is between one and three months.</p><p>- Chronic or progressive proptosis: if the evolution time of proptosis exceeds three months.</p><p>- CT scan quantifies proptosis in:</p><p>• Grade I: more than 2/3 of the eyeball is in front of the external bicanthal line.</p><p>• Grade II: the external bicanthal line affronts the posterior pole of the eyeball.</p><p>• Grade III: the entire eyeball is in front of the external bicanthal line.</p></sec><sec id="s2_4"><title>2.4. Data Collection and Analysis</title><p>The variables studied were:</p><p>- Demographic: age, sex.</p><p>- Clinic: reason for consultation, proptosis onset, characteristics of proptosis, degree of proptosis (Grade by CT scan), results of biological and anatomopathological test.</p><p>The data were entered into a database designed in Epi data software version 3.1. The descriptive and comparative statistical analysis of the population was performed using R Studio software version 3.4.3.</p></sec></sec><sec id="s3"><title>3. Results</title><p>A total of 42 children’s files were retained, over a total of 8367 files of children consulted during the study period, i.e. a frequency of proptosis of 0.5%.</p><sec id="s3_1"><title>3.1. Demographic</title><p>The mean age of children was 7.63 years &#177; 4.96 [4 days; 15 years]. The age range [0; 5 years] was predominant with 9 (38.10%) patients (see <xref ref-type="table" rid="table1">Table 1</xref>).</p><p>Twenty-four patients (57.14%) were boys and 18 were girls (42.86%), that is a sex ratio of 1.33 (see <xref ref-type="table" rid="table1">Table 1</xref>).</p></sec><sec id="s3_2"><title>3.2. Clinic</title><p>The main reason for consultation was proptosis found in 38 patients (90.48%), followed respectively by reduced visual acuity in 17 patients (40.48%) and eye pain in 11 patients (26.19%).</p><p>The average progression period of proptosis was 383.7 days with extremes ranging from 3 days to 10 years. Sixteen children i.e. 38.09% presented an acute proptosis.</p><p>The proptosis was unilateral in 80.95% of patients and 71.43% were axial proptosis. Proptosis were non-pulsatile in 97.62% of cases (see <xref ref-type="table" rid="table2">Table 2</xref>).</p><p>Twenty children out of 42 (47.62%) had performed an orbito-cerebral CT scan. The proptosis quantification by CT scan was 9.52% cases for grade I, 16.67% of cases for grade II and 21.43% of cases for grade III.</p><table-wrap id="table1" ><label><xref ref-type="table" rid="table1">Table 1</xref></label><caption><title> Patient distribution by age and sex</title></caption><table><tbody><thead><tr><th align="center" valign="middle"  rowspan="2"  ></th><th align="center" valign="middle"  colspan="2"  >Sex</th><th align="center" valign="middle"  rowspan="2"  >Total</th><th align="center" valign="middle"  rowspan="2"  >Percent (%)</th></tr></thead><tr><td align="center" valign="middle" >Female</td><td align="center" valign="middle" >Male</td></tr><tr><td align="center" valign="middle" >[0 - 5 years[</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >9</td><td align="center" valign="middle" >16</td><td align="center" valign="middle" >38.10</td></tr><tr><td align="center" valign="middle" >[5 years - 10 years[</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >13</td><td align="center" valign="middle" >30.95</td></tr><tr><td align="center" valign="middle" >[10 years - 15 years]</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >9</td><td align="center" valign="middle" >13</td><td align="center" valign="middle" >30.95</td></tr><tr><td align="center" valign="middle" >Total</td><td align="center" valign="middle" >18</td><td align="center" valign="middle" >24</td><td align="center" valign="middle" >42</td><td align="center" valign="middle" >100</td></tr></tbody></table></table-wrap><table-wrap id="table2" ><label><xref ref-type="table" rid="table2">Table 2</xref></label><caption><title> Patient distribution by the characteristics of the proptosis in children</title></caption><table><tbody><thead><tr><th align="center" valign="middle"  colspan="2"  ></th><th align="center" valign="middle" >Population</th><th align="center" valign="middle" >Percent (%)</th></tr></thead><tr><td align="center" valign="middle"  rowspan="2"  >Topography</td><td align="center" valign="middle" >Unilateral</td><td align="center" valign="middle" >34</td><td align="center" valign="middle" >80.95</td></tr><tr><td align="center" valign="middle" >Bilateral</td><td align="center" valign="middle" >8</td><td align="center" valign="middle" >19.05</td></tr><tr><td align="center" valign="middle"  rowspan="2"  >Direction</td><td align="center" valign="middle" >Axial</td><td align="center" valign="middle" >30</td><td align="center" valign="middle" >71.43</td></tr><tr><td align="center" valign="middle" >Non-axial</td><td align="center" valign="middle" >12</td><td align="center" valign="middle" >28.57</td></tr><tr><td align="center" valign="middle"  rowspan="2"  >Sensitivity</td><td align="center" valign="middle" >Painful</td><td align="center" valign="middle" >12</td><td align="center" valign="middle" >28.57</td></tr><tr><td align="center" valign="middle" >Painless</td><td align="center" valign="middle" >30</td><td align="center" valign="middle" >71.43</td></tr><tr><td align="center" valign="middle"  rowspan="2"  >Reducibility</td><td align="center" valign="middle" >Reducible</td><td align="center" valign="middle" >24</td><td align="center" valign="middle" >57.14</td></tr><tr><td align="center" valign="middle" >Non-reducible</td><td align="center" valign="middle" >18</td><td align="center" valign="middle" >42.86</td></tr><tr><td align="center" valign="middle"  rowspan="2"  >Pulsatility</td><td align="center" valign="middle" >Pulsatile</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >2.38</td></tr><tr><td align="center" valign="middle" >Non-pulsatile</td><td align="center" valign="middle" >41</td><td align="center" valign="middle" >97.62</td></tr></tbody></table></table-wrap><p>Ten children had carried out an infectious disease assessment which showed 4 (9.52%) cases of biological inflammatory syndrome and four of hyperthyroidism. Three children (7.14%) had carried out an anatomopathological examination.</p></sec><sec id="s3_3"><title>3.3. Etiology</title><p>An etiological diagnosis of proptosis was retained in 83.33% (35 cases). Tumor pathologies were at the forefront (35.71%), dominated by retinoblastoma in 46.67% of tumor pathologies. Then infectious and/or inflammatory pathologies in 14.29%, followed by orbital cellulitis in 66.67% of infectious and/or inflammatory diseases (see <xref ref-type="table" rid="table3">Table 3</xref>). Some pictures of the children received for proptosis at the eye department of CHU Campus of Lome (<xref ref-type="fig" rid="fig1">Figure 1</xref>, <xref ref-type="fig" rid="fig2">Figure 2</xref>).</p></sec></sec><sec id="s4"><title>4. Discussion</title><p>The frequency of proptosis in children was 0.5%. Our observation is similar to that of Koki et al. [<xref ref-type="bibr" rid="scirp.128956-ref2">2</xref>] who reported a frequency of 0.3% in a prospective and descriptive study of proptosis in children.</p><sec id="s4_1"><title>4.1. Demographic</title><p>The mean age of children presenting proptosis was 7.63 years, with a predominance of the 0 to 5 age range in 38.10%. This result is close to that of Ghosh and Dey [<xref ref-type="bibr" rid="scirp.128956-ref9">9</xref>] , who reported a mean age of 7.5 years, but different from that of Koki et al. [<xref ref-type="bibr" rid="scirp.128956-ref2">2</xref>] , whose 10 to 15 age range was the most represented in 47.4% of cases. Socio-demographic disparities and differences in sample size between studies could explain this discrepancy. A predominance of males was noticed, with a sex ratio of 1.33. These results concur with those of Chandana et al. [<xref ref-type="bibr" rid="scirp.128956-ref10">10</xref>] and Koki et al. [<xref ref-type="bibr" rid="scirp.128956-ref2">2</xref>] , who respectively reported a sex ratio of 1.77 and 1.9.</p><table-wrap id="table3" ><label><xref ref-type="table" rid="table3">Table 3</xref></label><caption><title> Etiology distribution of proptosis</title></caption><table><tbody><thead><tr><th align="center" valign="middle" ></th><th align="center" valign="middle" >Population</th><th align="center" valign="middle" >Percent (%)</th></tr></thead><tr><td align="center" valign="middle" >Tumor Pathologies</td><td align="center" valign="middle" >15</td><td align="center" valign="middle" >35.71</td></tr><tr><td align="center" valign="middle" >Retinoblastoma</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >46.67</td></tr><tr><td align="center" valign="middle" >RMS</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >20</td></tr><tr><td align="center" valign="middle" >Sinonasal carcinoma</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >20</td></tr><tr><td align="center" valign="middle" >Undefined tumors</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >13.33</td></tr><tr><td align="center" valign="middle" >Infectious and or inflammatory pathologies</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >14.29</td></tr><tr><td align="center" valign="middle" >Orbital cellulitis</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >66.67</td></tr><tr><td align="center" valign="middle" >TPI</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >33.33</td></tr><tr><td align="center" valign="middle" >Thyroid Pathologies</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >9.52</td></tr><tr><td align="center" valign="middle" >Basedow’s Disease</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >100</td></tr><tr><td align="center" valign="middle" >Birth defects</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >7.14</td></tr><tr><td align="center" valign="middle" >Crouzon syndrome</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >100</td></tr><tr><td align="center" valign="middle" >Trauma</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >7.14</td></tr><tr><td align="center" valign="middle" >Other causes</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >9.52</td></tr><tr><td align="center" valign="middle" >Congenital glaucoma</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >25</td></tr><tr><td align="center" valign="middle" >Corneal staphyloma</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >50</td></tr><tr><td align="center" valign="middle" >High myopia</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >25</td></tr><tr><td align="center" valign="middle" >Unknown Causes</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >16.67</td></tr></tbody></table></table-wrap><p>RMS: Rhabdomyosarcoma; TPI: pseudo-tumor inflammatory.</p></sec><sec id="s4_2"><title>4.2. Clinic</title><p>Orbital pathology usually shows as proptosis. Similarly, proptosis was the main reason for consultation, i.e. 90.48% of cases, which is similar to the findings of literature review with 100% and 62.90% respectively [<xref ref-type="bibr" rid="scirp.128956-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.128956-ref11">11</xref>] . Reduced visual acuity was the second most frequent reason for consultation in our study in 40%, as in the study of Dsouza et al. in 80% [<xref ref-type="bibr" rid="scirp.128956-ref1">1</xref>] . These results can be explained by the fact that proptosis and reduced visual acuity are a real esthetic and functional concern for parents. A delay in consultation was observed, with an average consultation time of 383.7 days, and 38.90% of patients who consulted within one month. Our results are comparable to those of Belmekki et al. [<xref ref-type="bibr" rid="scirp.128956-ref11">11</xref>] , who reported that 37% of patients consulted within one month. There may be many reasons for this, including difficult access to health centers, the influence of traditional medicine, poverty and cultural considerations.</p></sec><sec id="s4_3"><title>4.3. Etiology</title><p>The etiologies responsible for pediatric proptosis are generally unilateral [<xref ref-type="bibr" rid="scirp.128956-ref12">12</xref>] [<xref ref-type="bibr" rid="scirp.128956-ref13">13</xref>] [<xref ref-type="bibr" rid="scirp.128956-ref14">14</xref>] . Proptosis was predominantly unilateral in 80.95% of cases; Chandana et al. [<xref ref-type="bibr" rid="scirp.128956-ref10">10</xref>] made the same observation, but in 75.60% of cases. It was predominantly left-sided (52.38%), unlike the study of Dsouza et al. [<xref ref-type="bibr" rid="scirp.128956-ref1">1</xref>] , where it was predominantly right-sided. In 71.43% of cases, proptosis was axial, as reported in the literature review [<xref ref-type="bibr" rid="scirp.128956-ref2">2</xref>] [<xref ref-type="bibr" rid="scirp.128956-ref15">15</xref>] . In the present study, tumor pathologies were at the forefront, with 35.71% of cases, and 46.67% of retinoblastoma. Koki et al. [<xref ref-type="bibr" rid="scirp.128956-ref2">2</xref>] made the same observation, with 31.60% of tumor pathologies, and 33.40% of retinoblastoma. Other studies report that the primary cause of proptosis in children is inflammatory and/or infectious, dominated by orbital cellulitis [<xref ref-type="bibr" rid="scirp.128956-ref9">9</xref>] [<xref ref-type="bibr" rid="scirp.128956-ref12">12</xref>] . Retinoblastoma was found in 71.43% of cases between the ages of 0 and 5 years. Indeed, according to the literature, the mean age of diagnosis of retinoblastoma is 2 years [<xref ref-type="bibr" rid="scirp.128956-ref16">16</xref>] [<xref ref-type="bibr" rid="scirp.128956-ref17">17</xref>] [<xref ref-type="bibr" rid="scirp.128956-ref18">18</xref>] . That reflects the delay in diagnosing childhood ocular tumors in general, and retinoblastoma in particular, in developing countries such as ours. Orbital cellulitis, which represented 9.52% of all causes of proptosis, was more common in the 5 - 10 age range, as reported in the literature [<xref ref-type="bibr" rid="scirp.128956-ref4">4</xref>] [<xref ref-type="bibr" rid="scirp.128956-ref19">19</xref>] .</p></sec></sec><sec id="s5"><title>5. Limitations of the Study</title><p>Several limitations of the study relate to its retrospective nature, as many data were not collected from the files. The monocentric nature of the study limits the generalizability of the results to all the country.</p></sec><sec id="s6"><title>6. Conclusion</title><p>Childhood proptosis is a rare but significant sign of underlying orbital pathologies. Tumor and infectious pathologies are dominant causes, and unfortunately, their diagnosis is often delayed. To minimize the risk of blindness associated with childhood proptosis, it is imperative to prioritize early diagnosis and establish a multidisciplinary approach for efficient care. Additionally, conducting multicenter studies will provide comprehensive data that can inform and improve the management strategies for childhood proptosis in our country. By implementing these measures, we can enhance the overall well-being and long-term visual outcomes for children with proptosis. The insights gained from this study can contribute to improving healthcare practices and intervention strategies for pediatric proptosis in Togo.</p></sec><sec id="s7"><title>Conflicts of Interest</title><p>The authors declare no conflicts of interest regarding the publication of this paper.</p></sec><sec id="s8"><title>Cite this paper</title><p>Maneh, N., Santos, M.A.K., Kawilitetou, K.S., Amouzou, D., Dzidzinyo, K., Vonor, K., Ayena, D.K. and Balo, P.K. (2023) Epidemiological and Diagnostic Aspects of Childhood Proptosis in Lome (Togo) from 2010 to 2020. Open Journal of Ophthalmology, 13, 333-340. https://doi.org/10.4236/ojoph.2023.134032</p></sec></body><back><ref-list><title>References</title><ref id="scirp.128956-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Dsouza, S., Kandula, P., Kamath, G. and Kamath, M. (2017) Clinical Profile of Unilateral Proptosis in a Tertiary Care Center. Journal of Ophthalmology, 2017, Article ID 8546458. https://doi.org/10.1155/2017/8546458</mixed-citation></ref><ref id="scirp.128956-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Koki, G., Sylla, F. and Traore, J. (2009) L’exophtalmie de l’enfant à l’Institut d’ophtalmologie tropicale de l’Afrique (IOTA). Med Trop, 69, 467-470.</mixed-citation></ref><ref id="scirp.128956-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Abba Kaka, H.Y., Guirou, N., Laminou, L., Traore, H., Moussa, M., Roufaye, L., et al. (2021) Etude clinique et épidémiologie de l’exophtalmie de l’enfant au Niger. Revue SOAO, 1, 32-36.</mixed-citation></ref><ref id="scirp.128956-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Hodges, E. and Tabbara, K.F. (1989) Orbital Cellulitis: Review of 23 Cases from Saudi Arabia. British Journal of Ophthalmology, 73, 205-208. https://doi.org/10.1136/bjo.73.3.205</mixed-citation></ref><ref id="scirp.128956-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Morax, S. and Badelonb, I. (2009) L’exophtalmie basedowienne. Journal Fran&amp;#231;ais d’Ophtalmologie, 32, 589-599. https://doi.org/10.1016/j.jfo.2009.09.001</mixed-citation></ref><ref id="scirp.128956-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Ducasse, A. (2009) Conduite pratique à tenir devant une exophtalmie. Journal Fran&amp;#231;ais d’Ophtalmologie, 32, 581-588. https://doi.org/10.1016/j.jfo.2009.04.020</mixed-citation></ref><ref id="scirp.128956-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Kayoma, D.H., Uhumwangho, O.M. and Osaguona, V. (2017) Aetiology and Demographics of Unilateral Proptosis in Benin City. Port Harcourt Medical Journal, 11, 166-169. https://www.phmj.org/text.asp?2017/11/3/166/237879  https://doi.org/10.4103/phmj.phmj_19_17</mixed-citation></ref><ref id="scirp.128956-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Ayena, K.D., Amegbor, K., Lawson, S.L.A., Koffi, K.S., N’timon, B., Nabroulaba, K.T., et al. (2012) Prise en charge d’un cas d’exophtalmie unilatérale due à un lipofibrome intra-orbitaire au CHU de Kara au Togo. Journal Fran&amp;#231;ais d’Ophtalmologie, 35, 626.e1-4. https://doi.org/10.1016/j.jfo.2012.04.007</mixed-citation></ref><ref id="scirp.128956-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Ghosh, S. and Dey, S. (2009) The Investigation of a Proptosis in Paediatric Practice. AMJ, 16, 36-43. https://doi.org/10.4066/AMJ.2009.59</mixed-citation></ref><ref id="scirp.128956-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Chandana, C., Nabanita, B., Rosy, K.C. and Subhadri, M. (2019) Retrospective Analysis of Clinical Profile of Pediatric Proptosis in a Tertiary Care Hospital of Eastern India. Journal of Clinical Ophthalmology and Research, 7, 117-121. https://doi.org/10.4103/jcor.jcor_73_18</mixed-citation></ref><ref id="scirp.128956-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Belmekki, M., Bakkali, M.E., Abdellah, H., Benchrifa, F. and Berraho, A. (1999) Epidémiologie des processus orbitaires chez l’enfant. Journal Francais d’Ophtalmologie, 22, 394-398.</mixed-citation></ref><ref id="scirp.128956-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">Sindhu, K., Downie, J., Ghabrial, R. and Martin, F. (1998) Aetiology of Childhood Proptosis. Journal of Paediatrics and Child Health, 34, 374-376. https://doi.org/10.1046/j.1440-1754.1998.00243.x</mixed-citation></ref><ref id="scirp.128956-ref13"><label>13</label><mixed-citation publication-type="other" xlink:type="simple">Otulana, T.O., Sogebi, O.A., Ajibode, H.A., Bodunde, O.T. and Onabolu, O.O. (2016) Etiological Pattern, Clinical Presentation, and Management Challenges of Proptosis in a Tertiary Hospital in South West Nigeria. The Nigerian Journal of General Practice, 14, 28-32. https://doi.org/10.4103/1118-4647.189746</mixed-citation></ref><ref id="scirp.128956-ref14"><label>14</label><mixed-citation publication-type="other" xlink:type="simple">Sharma, B., Sharma, A. and Thatte, S. (2018) Etiological Prevalence of Proptosis: A Prospective Study. Journal of Medical Science and clinical Research, 6, 482-488. https://doi.org/10.18535/jmscr/v6i8.76</mixed-citation></ref><ref id="scirp.128956-ref15"><label>15</label><mixed-citation publication-type="other" xlink:type="simple">Masud, Z.S. and Bano, S. (2003) Diagnostic Role of CT Scan in Proptosis in Paediatric Age Group. Journal of Postgraduate Medical Institute, 18, 439-442.</mixed-citation></ref><ref id="scirp.128956-ref16"><label>16</label><mixed-citation publication-type="other" xlink:type="simple">Aerts, I., Rouic, L.L., Gauthier-Villars, M., Brisse, H., Doz, F. and Desjardins, L. (2006) Retinoblastoma. Orphanet Journal of Rare Diseases, 1, Article Number: 31. https://doi.org/10.1186/1750-1172-1-31</mixed-citation></ref><ref id="scirp.128956-ref17"><label>17</label><mixed-citation publication-type="other" xlink:type="simple">Zuker, J.M., Desjardins, L., Stoppa-Lyonnet, D. and Doz, F. (2005) Rétinoblastome. EMC-Pédiatrie, 2, 332-331. https://doi.org/10.1016/j.emcped.2005.09.002</mixed-citation></ref><ref id="scirp.128956-ref18"><label>18</label><mixed-citation publication-type="other" xlink:type="simple">Doz, F. (2006) Rétinoblastome: Aspects récents. Archives de Pédiatrie, 13, 1329-1337. https://doi.org/10.1016/j.arcped.2006.06.017</mixed-citation></ref><ref id="scirp.128956-ref19"><label>19</label><mixed-citation publication-type="other" xlink:type="simple">Mouriaux, F., Rysanek, B., Babin, E. and Cattoir, V. (2012) Les cellulites orbitaires. Journal Fran&amp;#231;ais d’Ophtalmologie, 35, 52-57. https://doi.org/10.1016/j.jfo.2011.08.004</mixed-citation></ref></ref-list></back></article>