This was a prospective descriptive study from November 2020 to April 2021 in the neonatology department of Issaka Gazoby maternity hospital in Niamey, a national referral center.

The study focused on newborns aged 0 to 28 days hospitalized in the department for seizures, or those who had convulsed during hospitalization. Polymalformed newborns were not included. Parental consent was a prerequisite for inclusion in the study. The diagnostic criteria of the World Health Organization (WHO) were used for perinatal asphyxia (Apgar score less than 7 at 5 minutes after birth), and those of the “Agence Nationale d’Accréditation et d’Evaluation en Santé (ANAES, 2000)” for the diagnosis of maternal-fetal infection (such as chorioamniotitis, maternal fever at delivery or premature rupture of membrane) [5] [7] .

The socio-demographic characteristics of the mothers and the maternal risk of neonatal infection during pregnancy were studied first. Next, the characteristics of the newborns were explored (gestational age, Apgar score, notion of resuscitation at birth, sex and birth weight). Clinical aspects (age of onset of first seizure, admission mode, temperature, seizure semiology), biological examinations, etiologies and evolution of the newborns were then studied. Data processing and analysis were done using SPSS version 20 software.

The average age of the mothers of the newborns was 25.3 years [16 - 41 years]. The majority (95.7%) had not medical or surgical history. Maternal fever was the most common neonatal infectious risk, accounting with 46.4% of cases. Most pregnancies (84.1%) were well monitored.

The Table 1 shows the characteristics of the newborns. The majority were born at term (94.2%). The Apgar score at 5 minutes after birth was less than 7 in 53.6% of cases, and all these newborns benefited from resuscitation. Birth weight was between 2.500 g and 3.999 g in 72.5% of cases. Males were more represented with 55.1% of cases, for a sex ratio of 1.22.

Newborns were referred from other health facilities in 72.5% of cases. The first attack occurred between birth and 3 days in 89.9% of newborns. Temperature was normal, between 36.5˚C and 37.5˚C in 76.8%. Neurological examination was also normal in 98.6% of cases post-critically. Seizures were repeated in 68.1% of newborns. Convulsions lasted less than 5 minutes per seizure in 97.1% of cases. The distribution of seizure types is shown in Table 2. Generalized crises occurred in 50.7% of newborns.

Respiratory distress was the sign most frequently associated with convulsions, found in 41.7% of newborns. On the biological level, more than eight out of ten newborns (85.5%) had a leukocytosis greater than 25.000 elements/mm³. C-reactive protein was positive (greater than 6 mg/L) in 27.5% of cases, as was thick and thin smear in 13.04% of newborns. Etiologies are shown in Table 3. Congenital malaria was isolated in 7.2% of newborns. As for metabolic disorders, hypoglycemia was found in 33.3% of cases, hypocalcemia in 17.2% and hyponatremia in 21.4%. These were isolated in 5.8% of newborns. Perinatal

* Hypoglycemia, hypocalcemia and et hyponatremia.

asphyxia and early-onset neonatal infection were the most common pathologies, accounting for 46.4% and 40.6% of cases respectively.

More than four out of ten newborns (43.5%) had spent between one (1) and five (5) days in the department. Newborns were discharged without clinical sequelae in 79.7% of cases. The case fatality rate was 20.3%. Death occurred between one (1) and three (3) days of life in 42.9% of cases. The main causes of death were perinatal asphyxia (50%) and maternal-fetal infection (21.4%).

The prevalence of neonatal seizures has been variously reported in the literature, fluctuating between 1.5% and 14% [11] - [16] . The low rate funded in our context may be due to diagnostic difficulties, many seizures going clinically undetected, and others having only an isolated electrical translation. The decline in incidence of this condition worldwide could be explained by advances in resuscitation methods [5] [17] [18] . In our context, this involved training health workers in emergency obstetric and neonatal care in peripheral health centers.

The majority of seizures cases were observed in full-term infants (84.1%), as reported by Kojmane et al. [12] and Ghanshyambhai et al. [14] , with 84% and 94% of cases respectively. In the present study, neonates presented with their first seizure within the first three days after birth in 89.9%. Neonatal seizures generally occur during the first few days of life, notably the first week of life in 80% of cases [1] [12] [19] . Seizures in newborns are highly polymorphic. In this series, generalized crises accounted for 50.7% and partial seizures for 49.3%. Clinical manifestations have been variously reported in the literature. In the study by Haque S and et al. a predominance of partial seizures was reported in 53.3% of cases, generalized seizures in 10%, and no cases of myoclonic seizures [19] .

Neonatal seizures are a non-specific manifestation of many neurological and biochemical disorders. It was often difficult to define a precise etiology seizures when several factors were simultaneously involved. The etiological profile of neonatal seizures has changed in recent decades [19] [20] . In this study, perinatal asphyxia represented the most frequent cause of seizures, as reported in other series [1] [19] [20] . In our context, and in developing countries in general, this situation could be explained by inadequate or absent monitoring of pregnancies and poor delivery conditions [5] . Early-onset neonatal infection, the second most common cause, could be explained by poor hygiene conditions in health facilities [5] [18] . Metabolic disorders, notably hypoglycemia, have also been described as an important cause of seizures in the neonatal period [1] [7] [8] [9] [10] [12] [19] . In this study, the low rate of hypoglycemia found could be linked to the systematic administration of glucose to any newborn presenting with adaptation disorders or neurological signs.

The prognosis of neonatal seizures remains severe, as not only the mortality rate but also the neurological sequelae must be considered [1] [4] [21] . In this study, the mortality rate was 20.3%, with perinatal asphyxia as the main cause of death. A similar mortality was reported by Haque S et al. with 20% [19] . In addition to its high case-fatality rate, perinatal asphyxia is one of the most frequent causes of neurodevelopmental sequelae in children [1] [17] [19] [22] . Those reported in the literature were cerebral palsy, mental retardation and epilepsy. This situation could be explained by the limits of diagnostic, therapeutic and monitoring resources in our context. Prevention therefore remains essential. It requires well-followed prenatal consultations, adequate fetal monitoring, early management and mastery of resuscitation techniques in the delivery room.