This study included 860 patients who underwent argon plasma coagulation (APC) or endoscopic mucosal resection (EMR) for colorectal polyps in the Department of Gastroenterology of the First Affiliated Hospital of Yangtze University between January 2020 and December 2021 as study subjects. The patients were divided into experimental and control groups according to the random number table method, with 430 patients in each group. The inclusion criteria were as follows: 1) colorectal polyps treated with APC or EMR and 2) informed consent from patients and their families and signed the informed consent form. Exclusion criteria were as follows: 1) patients with diabetes; 2) patients with obvious bleeding tendency; 3) patients with mental disorders and serious cardiovascular diseases who could not cooperate; 4) patients who refused to undergo endoscopic treatment, refused to follow medical advice, were automatically discharged from the hospital, and had incomplete clinical data. The study was approved by the Ethics Committee of the First Affiliated Hospital of Yangtze University. Exclusion criteria: Those who withdrew midway or fasted for more than 24 h after surgery.

Patients in the control group were administered 3 L of polyethylene glycol electrolyte bulking regimen in divided doses for preoperative bowel preparation [6] , that is, a clear liquid diet 1 d before surgery, 1 L at 8:00 pm. 1 d before surgery, and 2 L 6 h before surgery until the patient passed clear watery stools and then underwent endoscopic surgery at the endoscopy center between 8:00 am and 12:00 pm. Bowel preparation quality was rated by the operator using the Boston bowel preparation scale (BBPS) [7] . After the operation, the patients fasted for 24 h. Short-term intravenous nutritional support was provided in the form of rehydration fluids, with a basal rehydration volume of 2000 ml, specifically, a low-rate intravenous drip of 10% dextrose injection 500 ml + 5% dextrose injection 500 mL + 10% dextrose injection 500 ml + 500 mL dextrose sodium chloride injection. After 24 h, the fluid diet was opened and the mice were transitioned to a normal diet after 1 week. The nurses on duty monitored the patients’ finger blood glucose at 1, 4, and 8 h after the completion of postoperative intravenous infusion or when there were symptoms such as panic and cold sweat, respectively. Diagnostic criteria of hypoglycemia [8] : blood glucose < 3.9 mmol/L was considered as hypoglycemia, or blood glucose ≥ 3.9 mmol/L, but there were hypoglycemic reactions such as hunger, panic, dizziness and cold sweat. Those who had hypoglycemia or hypoglycemic reaction during the fasting period were administered 50% glucose injection 20 - 40 ml intravenously or 10% glucose injection 250 ml intravenously, and the terminal blood glucose was retested after 30 min.

The patients in the experimental group were administered oral glucose intervention on the basis of the control group, that is, 1 d before the operation, 1 L of polyethylene glycol electrolyte dispersion plus 40 ml of oral 50% glucose solution at 8 pm on the first day, 2 L of polyethylene glycol electrolyte dispersion plus 60 ml of oral 50% glucose solution 6 h before the operation, and the rest was the same as the control group.

To observe the incidence of postoperative hypoglycemia, the quality of bowel preparation, and tolerance of patients during bowel preparation in the two groups.

SPSS 22.0 software was used for statistical analysis of the data. Mean ± SD was used to describe the data of continuous variables, and ANOVA or chi-square test was used for comparison between groups, and P < 0.05 was considered a statistically significant difference.

A total of 860 patients were divided into the experimental and control groups according to the random number table method (n = 430). Seven patients were withdrawn in the middle of 860 cases: four cases of postoperative gastrointestinal bleeding and fasting time of more than 24 h in the control group, 426 cases were included; three cases of postoperative gastrointestinal bleeding and a fasting time of more than 24 h in the experimental group, and 427 cases were included. In the control group, there were 216 males and 210 females, aged 24 - 86 years, with a mean of (44.83) years, 348 cases undergoing APC and 78 cases undergoing EMR. In the experimental group, there were 209 males and 218 females aged 32 - 83 years, with a mean of (47.33) years, 344 cases of APC, and 83 cases of EMR. There was no statistically significant difference between the baseline data of the two groups (P > 0.05) (See Table 1).

The mean blood glucose values at 1 h and 4 h after infusion in the experimental group were higher than those in the control group (9.23 mmol/L vs. 8.82 mmol/L, P = 0.046; 7.36 mmol/L vs. 7.1 mmol/L, P = 0.048); the mean blood glucose values at 8 h after infusion in the experimental group were higher than those in the control group. Although the difference was not statistically significant, it was still slightly higher than that of the control group (5.53 mmol/L vs. 5.35 mmol/L, P = 0.69). The incidence of postoperative blood glucose < 3.9 mmol/L,

Note: APC: Argon Plasma Coagulation; EMR: Endoscopic Mucosal Resection.

the incidence of hypoglycemic reaction, and the incidence of hypoglycemia were significantly lower in the experimental group than in the control group (3.75% vs. 10.09%, P = 0.000; 1.17% vs. 3.29%, P = 0.036; 4.92% vs. 13.38%, P = 0.000) (See Table 2).

The Boston Bowel Preparedness Scale scores the colon into three segments (cecum and ascending colon, hepatic flexure, transverse colon and splenic flexure, descending colon, sigmoid colon, and rectum), with a score of 0 to 3 for each segment and a total score of 0 - 9. A score > 2 for each segment of the colon indicated adequate bowel preparation; a total score < 6 or a score < 2 for any segment of the colon was considered inadequate bowel preparation [7] . The difference in BBPS scores between the experimental and control patients was not statistically different (6.46 vs. 6.34, P = 0.729). In terms of tolerability, adverse reactions (such as nausea, vomiting, abdominal pain, bloating, cold sweats, hunger, dizziness, fatigue, and palpitations) during bowel preparation were recorded using a questionnaire after completion of bowel preparation in the two groups. Again, there was no statistical difference in the overall incidence of adverse reactions between patients in the experimental and control groups (12% vs. 16%, P = 0.09).