This is a retrospective study of patients treated for traumatic brain injury admitted to the Emergency Department (ED) of two major emergency hospitals—the Emergency Medicine Institute (EMI) and the Valentin Ignatenco Municipal Children’s Hospital (MCH) in 2018, in Chisinau municipality, the capital of Republic of Moldova, with a population of nearly 800,000 inhabitants. There has been used data from the INITIatE TBI Retrospective Registry, piloted for the first time in the country, part of the international project—INITIatE (International Collaboration to increase Traumatic Brain Injury Surveillance in Europe). A data collection tool (questionnaire) was developed. Data for this pilot project were coordinated nationally by the Nicolae Testemitanu State University of Medicine and Pharmacy from the Republic of Moldova, and internationally by the Department of Public Health, Babeș-Bolyai University, Cluj-Napoca and College of Public Health, the University of Iowa.

All patients of all ages with an ICD 10 code indicating any type of head injury, who received care at EMI and MHC in Chisinau, between August 1 and October 31 2018 were included in the analysis. The selected time period was constrained by the requirements of the pilot project and the total number of injuries that were needed to pilot test the instrument retrospectively; further on, to serve as a prospective data collection basis. All patients in the ED who corresponded to the definition of TBI included in the patient medical records within the set-up period served as a case for further observations. For 2018, in the Emergency Medicine Institute, where hospitalized a total of 77,245 patients, of which 22,724 injured, 699 TBI related (this is a republican hospital, the total population of RM being 2,640,000 citizens; in the Municipal Children’s Hospital where hospitalized a total of 46,848 patients, of which 11,300 injured, 639 TBI related (this is a municipal hospital, the total municipal population is 779,000 citizens).

A data collection form was developed based on existing guidelines from the World Health Organization and US registries. One resident in neurosurgery and a scientific researcher trained in data collection and coding procedures, collected data by hand from the patients’ medical records. Collected variables were defined by the INITIatE TBI Retrospective Registry, and after collection, the information was uploaded into computer databases using the existing electronic data collection tool—Red Cap. The study form (questionnaire) contains the patient’s general data and 4 modules with close-ended questions. The main module includes general information about the patient, date and time of injury, type of address and TBI type according to ICD-10. The following modules refer to: information about the patients external risk factors (place of injury occurrence, intent, type and mechanism), traumatic brain injury at the pre-hospital level (neurological assessment, ABS, vital signs, GSC, consciousness state, diagnosis tests), traumatic brain injury at the hospital (mechanical ventilation, antiseizure and hyperosmolar medication, surgery performed, ICP monitor/ventriculostomy placed) and patient discharge information (date and diagnosis code of discharge, principal cause of death in case of death).

The unit of our analysis was the TBI injured patient, who received care within both emergency departments of Emergency Medicine Institute and Valentin Ignatenco Municipal Children’s Hospital in Chisinau municipality, Republic of Moldova. Data from the study form relates to all the variables included in the INITIatE TBI Retrospective Registry. There has been collected general data, such as: age, sex, employment and social status, followed by specific variables related to TBI, such as: information about the patient’s external risk factors (place of occurrence, intent, mechanism, alcohol and drug screening), pre-hospital diagnosis (GCS Score, ABC Status on arrival, vital signs, ACE and confounding factors), hospital diagnosis and patient discharge information.

Descriptive statistics for TBI patients were calculated using t-tests and the significance threshold “p” (p < 0.05), necessary for testing the statistical significance. SPSS Statistics Base 20.0.0 was used to analyze data. Chi-square tests were used to determine if the distribution of injury intent and injury mechanism varied by age stratified by sex. Also, Chi-square tests were used to see if the sex, age, injury intent, and injury mechanism distribution differ by disposition. Statistical significance for the X² tests was set at p < 0.05.

During the study period, within both hospitals, Valentin Ignatenco Municipal Children’s Hospital and Emergency Medicine Institute, 150 patients were treated for head injury, of which 122 (81.3%) were male and 28 (18.7%) were female (Table 1). There have been 57 cases (38.5%) of TBI among children, aged between 0-18 years old; most cases being in the age group 0 - 6 years old (48.3%), followed by the age group of 10 - 14 years old (21.4%). Among adult TBI patients, were 93 cases (61.5%), aged between 18 - 73 years old, of which most cases being in the age group of 36 - 59 years old (29.1%), followed by age group of 19 - 35 years old (18.7%) and >60 years old (13.7%). The highest proportion of head injuries occurred among employed individuals 29.3% followed by unemployed and students (each by 21.3%), agriculture field (2%), industry and housewife (each by 0.6%). Employment was unknown for 22.6% of the patients.

A large majority (62%) of head injuries were among patients from the urban area (most in adults—60% and male—74%) (Table 2).

The most common mechanisms of head injury were falls (53.3%) and road traffic injuries (24%), followed by assault (14.7%) and struck by/or against (8%). The distributions by place of occurrence highlighted that most injuries occurred at home (33.4%) and transport areas (25.3%), followed by industrial or construction areas (12.6%), sports and recreation areas (12%), and farm or other places of primary production (9.3%). The data indicate that most injuries that happen at home are among children (43.9%) and the elderly (42.9%). There is significant relationship between these variables (p = 0.01); half of which is among females. Injuries within the transport area vary more among males (26.3%), and those aged 19 - 35 years old (42.9%) and 36 - 59 years old (25%). In an equal measure (19.1%) the elderly gets injured in transport area, farm or other places of primary production.

The majority of head injuries (88%) were mentioned as unintentional, mostly among children and the elderly and 12% of head injuries were the result of assault, mostly in the male, age group of 36 - 59 years old.

The majority of the cases were not work related 139 (92.7%) equally distributed by gender; however, for 11 (7.3%) work related cases, with no case in children, the majority of cases were within the age group 36 - 59 years old (6, 13.6%), and male (9, 7.4%).

A large proportion of patients asked for ambulance help (81.3%, there is significant relationship between these variables, p = 0.01). The most requested periods of the day with head trauma were recorded between 8.00 - 12.00 for 35 (23.3%) patients (mostly elderly and children) and 16.00 - 20.00 for 34 (22.6%) patients. Presents the interests, distribution of cases according to the time of the day and mechanism of injury: most of the assaults registered from the noon to 8.00, falls in the period of 8.00 - 12.00 and road traffic injuries within 12.00 - 16.00, there is significant relationship between these variables (p = 0.002).

The level of consciousness of the TBI patients was compared using GCS at the injury site and emergency department.

Pre-hospital, 83.9% of the TBI patients had a GCS of 13 to 15, indicating a minor TBI; their status remained stable and did not change at ED. The 9.4% of patients with a GCS of 9 - 12, indicating a moderate TBI, also remained stable from the field to ED. GCS scores varied between 0.7% and 1.3% of patients with a GCS of 8 in the pre-hospital period and ED indicating severe brain injury, Coma I. While, in the case of the injured in Coma II, GCS of 6-7p, there was observed an improvement in the injured consciousness status from 3.3% to 2.7%, respectively. No changes in the Coma III, GCS 4-5 for 2.7% of cases, and no patients were registered in the Coma IV, GCS of 0-3p. The data resulting from the comparison of GCS indicators at the pre-hospital level with those within the ED leads us to believe that they have not changed and that the parameters of health indices have not changed if summarized up into minor, moderate, or severe GCS.

Depending on the time of seeking specialized medical help, some changes were observed (Table 3).

Patients treated within the first hour after receiving specialized medical assistance following trauma were: 54.5% children under the age of 18 years old, followed by the elderly over the age of 60 years old (18.2%). The majority of addresses after specialized medical care were reached by ambulance (68.2%). Addresses after medical assistance for up to one hour took occurred in the home environment (54.5%), followed by road traffic injuries (13.6%), and the same locations remain when compared with the medical addresses between 1 - 4 hours (31.2% and 23.7%, respectively). After 4 hours and more after the TBI, addresses after medical care were from those cases due to road crashes (30.4%), followed by false (27.5%). We note that none of those who were addressed within the first

hour of receiving assistance showed significant changes, only a case of transition from 14p GCS to pre-hospital to 15p GCS to ED. GCS changes slightly in patients who are referred for help between 1 - 4 hours after trauma and no changes in patients who are addressed for medical assistance after 4 hours.

Presents an interest in the gender distribution of GCS (Table 4). In total, 121 (81.2%) head injuries were registered among men, with a predominance in minor GCS (65.1%), followed by moderate GCS (9.4%), while all cases in women are with GCS minor (18.8%).

From the total number of TBI patients, 80 (53.3%) cases of TBI have been identified as a result of falls (Table 5), aged between 0 - 88 years old, of which 61 (76.3%) were male and 19 (23.8%) female. Most cases of falls occur among children with 36 (45% cases), followed by the age group of 36 - 59 years old with 21 (26.3%). The age group of >60 years old is on the 3rd place with 13 (16.3%) and the age group of 19 - 35 years old with 10 (12.5%). More than half of the cases were related to urban areas (51, 63.8%). For all age groups, falls are associated with home, in 46 (57.5%) cases (mostly among children and the elderly); followed proportionally among farm or other place of primary production and industrial or construction areas (mostly among the age group of 36 - 59 years old) by 12.5% each. Most of the cases were not work-related (92.5%) and 7.5% were work-related among the age group of 19 - 59 years old. TBI patients who have fallen, take ambulance in proportion of 87.3%, there is significant relationship between these variables (p = 0.01). According to the time of injury, the majority of cases occur within 8.00 - 12.00 with 28.8% (mostly among children and elderly); following the period of 16.00 - 20.00 with 22.5% and 20.00 - 00.00 with 20% (mostly among children and age groups of 36 - 59 years old and 19 - 35 years old).

From the total number of TBI patients, there have been identified 36 (24%) cases of TBI as a result of road traffic accidents (Table 6), aged between 0 - 73 years old, of which 58.3% were male adults and 41.7% were young minors until 18 years old (22.2% male, 19.4% female). Most of the patients are students aged 15 - 17 years and 25 - 29 years old (39.4%), followed by those employed aged 30 years

or more (27.3%), unemployed (21.2%), and agriculture (3%). All cases of road injury were unintentionally, with only 8.3% of adult males reporting work-related injuries. Although TBI cases as a result of road accidents are proportionally distributed in both rural and urban areas, there is a significant relationship between these variables (p = 0.03). Additionally, most cases occurred among children from urban areas and the age group of 19 - 35 years old in rural areas. Distribution by sex, underlines most case with males in rural areas and most cases with females in urban areas. Most patients reach the hospital by ambulance, and only 11.1% walk-in. All adult patients were diagnosed with intracranial injury, sequel (S06.xxxS) sequel, while minor patients were diagnosed with other specified injuries of the head, sequel (S09.8xxS). Cases of TBI within road accidents (83.3%) have taken place in transport areas (public highways, streets or roads) and the most affected age group is children. So far, 16.8% of cases from total, mostly

in the age group under 18, mention other specified places of occurrence, as assessing retrospectively we cannot get the occupant role and identify risk factors for the crash.

During the study period, most cases were recorded in August (52.8%); from total—most cases of accidents being registered 12.00 - 16.00; particularly per ages: 16.00 - 20.00-monstly among children under 18 years old (6, 40%). Data on addressing patients after medical assistance at ED departments indicates an equal distribution of addresses between 1 - 4 hours and 4 hours and more (44.4%) and only 4 (11.1%) in the first hour after trauma.