This study was carried out at the “groupement” of South Mbinga (1˚45' North and 2˚29' South and its longitude is between 23˚40' and 29˚) in the Buhavu chiefdom (or chefferie) in the Kalehe territory, which is one of the 8 territories of South Kivu, eastern DR Congo. According to weather conditions, Kalehe has a humid tropical climate characterized by rugged topography with hill ranges varying from 1300 to over 2000 m above sea level. This area is characterized by two alternating seasons: the rainy season (September to May) and the dry season (June to August). The annual temperature varies between 18˚C and 22˚C with annual rainfall ranging between 1300 and 1680 mm, but the land cover change affects the climate by their variability. The Kalehe territory’s vegetation is dominated by forest including bamboo and shrubs which are frequently converted into urbanized areas, small-scale mining exploitation and agricultural land [31] . Kalehe communities generally practice small-scale crop and livestock farming, which are considered the main sources of household income [31] . The most common type of farming is family farming, which is practiced by over 70% of households. The location of study area is presented in Figure 1.

Sampling and data collection: The characteristics of the households, the farmers’ perceptions on the rabbit diseases and the management of rabbit diseases were collected from 100 farmers randomly selected in the study area. Data collection was done in local languages (Kiswahili and Kihavu) to facilitate data collection based on the objectives.

Biological materials: In all, 36 diseased rabbits with mange symptoms and lesions including 12 rabbits treated with zero times per day of the solution, 12 rabbits treated with one time per day of the solution and 12 other rabbits treated with two times per day of the solution of palmist oil (70%) associated with kerosene (30%) and rinsing with KMnO₄ solution. The treatment solution was made according to the recommendations of the experiment study of this solution on the control of ectoparasites on guinea pigs in Walungu [6] .

The Material of mixture and treatment: two (2) half-liters in plastic bottles containing the products, the chicken plume that permits the homogeneous mixture in these bottles and the application of this solution on the area presenting the mange scabies. The KMnO₄ tablets of 500 mg, after solution in water and after scrapping with a chirurgical knife, the KMnO₄ solution is applied by rinsing on the crusts.

Experimental design: The experimental design was a Randomized Complete Block Design (RCBD) with the rabbits’ treatment frequency as the single factor studied. Each cage contained 1 rabbit with symptoms and lesions. In addition, 3 treatment frequencies were considered: T0: no application of the product (control), T1: one application per day and T2: 2 applications per day. Number of cages: 18, distance between cages: 0.05 m, number of rabbits per cage: 2, surface area occupied by cages: 0.06 m², total surface area occupied by cages is 10.8 m² and total number of rabbits in the trial is 36 rabbits. The cages: 18 cages made of timber and galvanized wire mesh with a wire diameter of 2.2 and 2.5 mm and a space of 13 mm between two wires to allow the passage of excrement (faeces and urine). The experimental cages on the application rate of the traditional veterinary solution are presented in Figure 2.

Indeed, the samples of scabs and hair on animals with lesions on the surface of the skin and which are isolated and put in cages, where we have proceeded by scraping and rinsing superficial skin crusts by KMnO₄. The crusts are collected on the lesions preferably at the border or at several places of the skin especially around the head, back, rump, tail, genital area and interdigital area which are the preferential living places of the parasites and after these the oily solution will be put at already scraped areas.

Data collection was based on the individual interview using a questionnaire combination of observations in Kalehe during May 2021. The collected data were submitted to descriptive statistical analysis and the test of correlation and

significant differences were verified by the Statistical Package for the Social Science (SPSS) and the experimental data were submitted to statistical analysis by GenStat Discovery Edition 4.

Rabbit farmers in our study area are predominantly women (70%) compared to men (30%). Rabbit farming is practiced by young people aged on average 28 years with an average experience of 26 months, i.e. 2 years and 2 months and with farms having an average of 10 rabbits. Most rabbit farmers in the study area are educated to secondary level than other levels of education. Livestock (50%) and agriculture (25%) are considered as the main income sources than other activities such as trade (15%) and employment (10%).

The major part of the farmers in the study area would not associate rabbits (70%) with other animal species, while 30% of the farmers said they associate their rabbits with other animal species. Rabbit ear scabies (75%) was considered the most common disease in rabbits than fleas (5%), while 20% of farmers did not observe any disease in their rabbits. Poor livestock practices were identified by a majority (50%) of farmers as the main reason for the frequency of rabbit diseases in the study area, compared to the non-use of veterinary inputs (30%) and lack of information on good rabbit management practices (20%). In addition, 50% of the farmers used veterinary inputs for disease control and the other 50% did not use any veterinary inputs. Palmist oil combined with kerosene is the most used product (60%) compared to other veterinary products such as ivermectin (30%) and multi-vitamin (10%).

The results of the effectiveness of the palmist oil + kerosene solution application had a significant influence on the lesions on the lips, nose, ears, eyelids and on the rest of the body parts (p = 0.000). Indeed, the presence of lesions was observed on the nose of the control (3 lesions) compared to T2 (0.47). In addition, the application of the solution two times per day reduced the number of lesions to 1.2 lesions while 6.13 lesions were noted on the nose of rabbits housed in the control cages. Application of the solution 2 times per day reduced the number of lesions on the ears by 0.73 lesions compared to the application of the solution 1 time per day by 3.47 lesions. Application of the solution two times per day reduced the number of lesions on the eyelids, 0.47 lesions compared with T1 (3.47 lesions). T2 reduced the number of lesions on the limbs, 0.87 lesions compared with T0 (7.2 lesions).

The results in Figure 3 show the evolution of the symptoms and lesions according to the application of the palmist oil solution combined with kerosene. Indeed, the lesions presence on the rabbit’s organs changed with the frequency of the treatment of the rabbits with lesions. The lesions were reduced by applying the solution two times per day on the body parts of the rabbits compared to the other applications on the organs of the rabbits to be treated.

The results in Figure 4 show the rate of healing and mortality due to the application of the palmist oil solution combined with kerosene. Indeed, all the untreated rabbits (100%) had died from the abundance of lesions on different parts of their bodies while 60% of the rabbits treated one time per day was healed and 40% had died. Finally, 90% of the rabbits receiving two treatments per day were healed and only 10% died due to the abundance of lesions on different body parts.

Rabbit farming is practiced by more women than men, in farms with an average of 10 rabbits and an experience of 26 months (2 years and 2 months) in rabbit farming. In addition, crop and livestock production are the main activities of the farmers in our study area, and the raising of large livestock is not frequently practiced (Table 1). Results from [19] found that the largest number of rabbit farmers in Kenya has an average experience of less than 3 years and these are similar to ours. The low experience of rabbit farming in our study area can be due to the fact that the farming of small animals such as rabbits and guinea pigs has long been neglected and misjudged by rural communities. It was only after the extension of the socio-economic and nutritional benefits of these animals that rural communities adopted them. In addition, the results of [17] show that gender is not a factor that affects rabbit production in the smallholder farming system, but our results show a high participation of women and youth in rabbit farming in our study area. This high proportion is explained by the high quality of rabbit meat and the increasing demand for rabbit meat for the commercialization of women, as they are the household managers in the rural areas. Our results are similar to those found by [32] .

According to [13] [14] and [33] , the lack of large livestock in Kalehe and other Kivu’s highlands region can be due to the fact that large livestock are the causes of spatial competition between humans and animals, that they are very demanding in terms of livestock management practices, and that large livestock are frequently the object of pillage and used as arms of war in conflict and post-conflict areas. Also, the scarcity of pasture areas due to poor access to land is also one of the causes of the discontinuation of large livestock farming in preference to small livestock farming [34] such as rabbits and other small animals. The main mode of the ectoparasites identification in the rabbit is the appearance of the clinical signs and these appear mostly on the head regions. In addition, farmers in our study area show that inappropriate livestock practices, lack of information on rabbit production, and non-use of veterinary materials are the causes of the high frequency of rabbit diseases in the study area (Table 2). Our results are similar to those of [35] , who showed that lack of information on livestock production as well as poor livestock management conditions are among the causes of the frequency of pathological risks in rabbit farming.

Legend: KMO₄: Permaganate of Potassium.

Our results show that 50% of the rabbit farmers use veterinary products to control rabbit ectoparasites. Ivermectin and palmist oil combined with kerosene are both among the main products more used to control ectoparasites (Table 2). Our observations are similar to those obtained in Kenya by [24] , in India by [36] and in Romania by [37] in demonstrating that ivermectin is the most used injection product on the rabbit ectoparasite control. Then results from [6] show that the combination of palmist oil with kerosene is also used as ectoparasite treatment in the guinea pig farming. Farmers in our study area use a traditional method of control ectoparasites in their farms. [16] had shown that diseases in rabbit farming is one of the main constraints for their production, but the major part of small scale farmers use traditional methods to control ectoparasites as it is the case in our study area.

The results show that the frequency of application of the palmist oil solution combined with kerosene affect significantly (p = 0.000) the presence of lesions on the rabbits’ organs studied (Table 3). On the other hand, the progression of the lesions was a function of the application frequency of the solution (Figure 3), which influenced the mortality or healing of the rabbits treated with the application of palmist oil combined with kerosene solution (Figure 4). Our results are similar to those obtained on guinea pigs by [6] in demonstrating that the management of disease animals with the combination of palmist oil and kerosene solution has effects on the reduction of ectoparasites especially in infested farms where the farming system remains traditional. The results of [36] are similar in showing that treatment of rabbits with a single injectable dose of Ivermectin completely eliminates Sarcoptes scabiei on rabbits. However, [38] [39] demonstrated that good practice in disease management is one of the key factors in rabbit production since diseases are one of the major problems limiting the development of rabbit farming. According to [35] , the best rabbit management depends on an adequate rabbit vaccination program as well as good sanitation in the rabbit house since the livestock farming environment is also one of the propagators of transmissible diseases in rabbits.

Legend: T0: control (zero application of palmist oil + kerosene solution); T1: one application per day of the solution; T2: two application per day of the solution; GA: General average; LSD: Least Significant Difference; CV: coefficient of variance.