Hypertension is a form of cardiovascular disorder that results from a wide range of inter-connected ontologies. Untreated and uncontrolled hypertension leads to structural and functional abnormalities of cardiovascular system, which ultimately harm the vital organs of body, e.g. heart, failure and chronic kidney diseases [1] . The experience with patients shows that prescribed drugs for treating hypertension diseases fail to work effectively, causing high mortality rates in African Ethic types. Whereas this situation has resulted in the query as to why the situation exists [2] . The study was conducted to investigate factors affecting the failure of hypertension drugs among patients suffering from the disease. Particularly, the study aimed at examining cultural, individual and financial factors affecting drug failure among Tanzania patients.

Cross-sectional descriptive comparative study was utilized, the study was conducted in two different hospitals in Mbeya and Njombe regions, which are Afya Medicare specialized clinic and Mbeya Referral Hospital in Tanzania. And 300 patients were recruited from the all two medical out patients general clinics of Afya Medicare specialized clinic and Mbeya Referral hospital. The eligible respondents were selected by systematic randomized controlled sampling method. The study was conducted for a period of 4 months from August to November 2021.

The demographic and clinical characteristics of the 300 individuals, who were identified at the study site, are as described below:-

Table 1 shows the Gender of individuals with hypertension in interviewed in the study, according to the data observed, 51.3% of individuals were female and 48.7% were male. This implies that most of women especially in the southern highland s of Tanzania are Hypertension case, and this may be due to the lifestyle around the area.

Table 2 shows the frequency at which patients forget the intake of their medications, according to the observed data, 62.3% of individuals forget to take their medications on time and others forget completely to take the medication either purposely or unintended, and 37.7% do not forget their medications. The results imply that most of patients with hypertension fail to improve due to resistance of taking their medications as required and instructed. The graph (Figure 1) below illustrates more details.

Table 3 indicates the frequency of medication intake within the past two weeks where by 56.7% shows that most of the patients didn’t follow the medications as they were prescribed with their medical personnel, and 43.3% shows that they did not forget taking their medications in the past two weeks, these results imply that most of patients hate following the given procedures.

Table 4 indicates the frequency at which the patient has ever stopped or taken medication without consulting the doctor, whereby 62.0% of the interviewed individuals shows that they stopped medications without telling their medical instructors and 36.0% shows that they follow the instructions very well. These results imply that a high number of individuals with hypertension have resistance to medications due to ignorance and other factors such as social issues and lifestyle.

Table 5 shows that 52.3% of people when they travel or leave home they sometimes forget to take their medications with them, and 47.7% of people