In one year, 120 cases of nephrotic syndrome were recorded out of a total of 8061 children hospitalized in the pediatric department of the CHU Gabriel Toure in Bamako, either a hospital frequency of 1.5%.

1) Sex: There were more boys, 88 boys (73.3%) than girls (32, 26.7%) for an overall sex ratio of 2.75. Alongside this overall male predominance, we observed male exclusivity at the ages of one year, eight years and 14 years and an inversion at 13 years (sex-ratio = 0.33) (Figure 1).

2) Age: The median age was 6 years for an average of 6.4 years ± 2.4 years with extremes ranging from one year to 14 years. No case of infantile nephrotic syndrome was recorded and 16.67% of our patients were over 10 years old. Three peaks were observed at the ages of five years (largest peak), seven years and two years (Figure 1). Between five and seven years, 36.6% of patients were registered there with a sex ratio of 1.9.

1) Months of hospitalization: The nephrotic syndrome is observed throughout the year (Figure 2) with two peaks in the occurrence of cases, the first in summer (July-September) and the second in winter (December-February).

2) Origin: The patients came from the capital and from all regions of Mali: Bamako (47.5%), Koulikoro (19.2%), Kayes (13.2%), Sikasso (8.3%), Ségou (5.8%) and the central and northern regions of Mali (5.9%).

1) Ethnic groups: The main ethnic groups were the Bambara (40.8%), the Peulh (23.3%), the Sarakolé (11.7%), the Minianka-Sénoufos (10.9%) and the Malinké (9.2%). %), all melanoderms. No case of nephrotic syndrome has been recorded among Caucasian children in northern Mali.

2) Family cases: Two brothers from the same siblings had their first attack of nephrotic syndrome the same year, ten months apart.

Our hospital frequency was 1.5% (or 120 cases in one year) and was identical to that found by Keita Y at Aristide-Le-Dantec hospital in Dakar [8]. Our frequency was respectively higher than that found by NDongo A in Senegal (0.27% in two pediatric teaching hospitals) and that obtained by Savadogo H in Burkina-Faso (41 cases in two years) [9] [10]. This difference could be explained by the fact that the Gabriel TouréTouré UTH in Bamako is the national reference for the care of sick children and the non-feasibility of certain complementary examinations to confirm this pathology in remote areas of Mali.

A temporal variation in the frequency of NS (Figure 2, Table 1): This condition is rife throughout the year with a remarkable summer (June to August) and winter (December to February) periodicity. A summer peak was also found in Senegal and Iran [9] [11]. Our winter peak is similar to that of Tunisia [12]. In Mali, these peaks occur respectively in the rainy season during which we record a high prevalence of malaria and in the cool season when viral infections, particularly respiratory ones, are common [13]. Further investigations will be useful in order to specify the real place of these pathologies (factor triggering the first attack or as being a secondary etiology of the NS). According to Yap et al, a trivial viral infection, particularly of the upper airways, precedes the diagnosis of NS in one out of two cases [14]. According to Deschenes G et al, viral primary infections could be the environmental agents that trigger the disease when a specific genetic background is present [2].

The residence: The patients came from the capital and from all regions of Mali: Bamako (47.5%), Koulikoro (19.2%), Kayes (13.2%), Sikasso (8.3%), Ségou (5.8%) and the central and northern regions of Mali (5.9%). This disparate geographical distribution could be explained by the local population and endogamy in certain localities.

The temporal-spatial and ethnic variability of the SN suggests genetic determinism and environmental factors [1] [2] [3].

Sex: The overall sex ratio in our work was 2.75 higher than those observed by NDongo A (1.7) and Savadogo H (1.3) respectively from Senegal and Burkina Faso [9] [10]. In some populations, the sex ratio is three boys for one girl and this suggests the involvement of one or more genes carried by the X chromosome [1] [3].

Age: The distribution of age at onset is common across studies. In Bamako, nephrotic syndrome in children occurs at all ages but it is rare before one year of life. The median age of onset of 6 years is lower than that observed in Senegal which was 7.4 years and still lower than the average age in Burkina Faso which was 8.3 years [9] [10]. Further analysis is needed to understand this difference

between these Sahelian countries. In France, the median age of SNI was 4, which is lower than ours [3]. The analysis of Figure 1 in our work shows the precocity of the onset of this condition in Mali and 16.67% of our patients were over 10 years old. While in Burkina-Faso, adolescents aged 11 - 15 were predominant, which is a factor impacting the initial response to corticosteroids according to Savadogo [10].

Ethnic groups: The variability of incidence according to ethnic origin has been reported in several studies [15] [16]. Thus, in Mali many ethnic groups are concerned with two major findings:

· fairly high frequencies were observed among ethnic groups where the practice of endogamy is common (Peulh, Sarakolé and Miniaka/Sénoufo) [17]. A high prevalence of sickle cell disease has been associated with ethnic groups with high endogamy in Mali [18].

· a remarkable rarity of SN among children in northern Mali (leucoderma subjects) has been found.

Further studies will be needed to determine the link between endogamy, leucoderma, sickle cell disease and nephrotic syndrome in Mali.

Familial cases: The existence of familial cases suggests oligogenic determinism without Mendelian monogenic inheritance in most cases [1] [2] [3].