Leprosy has been with man for a very long time. Issues relating to leprosy or lepers were mentioned in the Holy Bible both in the Old Testament [5] and the New Testament [6] [7] [8]. It should be noted that in the Holy Bible, the term leprosy was used for different types of skin conditions including Hansen’s disease [5]. It was not until 1873 that Mycobacterium leprae, the cause of leprosy [or Hansen’s disease] was isolated [9] and the disease was properly defined. Mycobacterium leprae, an acid-fast bacillus, can be isolated from leprosy lesion. Segregation and stigma associated with leprosy were also mentioned in the Holy Bible, although the reasons were to prevent others from being infected.

Following infection, Mycobacterium leprae grows very slowly in human body causing damage to the body tissues [10] [11]. One of the complications of leprosy is loss of sensation which includes pain sensation. The consequence of this is that there is damage to some parts of the body, especially the hands and feet, due to repeated injury and scarring. The external manifestations of leprosy and the fear of contracting the disease are among what fuels stigma in leprosy [12].

Leprosy is a treatable disease [10]. However, the treatment for the disease sometimes results in adverse immunological reaction which can further damage the skin of the sufferer. In the past, lepers were segregated and made to live in colonies where they were treated [9].

The World Health Organization (WHO) recommends multidrug therapy for leprosy for effective treatment [10]. Early treatment will prevent or limit complications [10]. It will also prevent the spread of the disease to others. However, the problem is that the patient may not feel encouraged to declare his illness for fear of losing his job [2] or his place of residence, or he may not even be aware that the disease is treatable. The consequence of all these is that there is a delay in initiating treatment resulting in increased chances of body’s disfiguring by the disease and thus increased chances of stigma.

Even after the leprosy has been successfully treated, the stigma still persists because of the residual deformity to the hands, feet, body and eyes. Psychotherapeutic intervention is necessary to help the afflicted cope with his condition. Occupational rehabilitation is also important to enable him to earn a living. Such will keep him occupied most of the time and will make him think less of his ailment.

Hearing loss can occur at any age. However, hearing loss is very common among the elderly where the prevalence can be 50% or higher [13]. A person with severe hearing loss will have difficulty interacting with people [14]. The problem will even be worse if the person is also dumb. Hearing and/or speech impaired person may feel isolated and depressed. In a place where special school for the deaf and dumb is not available, he will not have the opportunity to attend formal education and this will further limit his opportunities in future. In children, hearing loss significantly impairs language development [15].

Hearing loss can be caused by physical or acoustic trauma, developmental anomaly or ear infections. Wax impaction is a common and treatable cause of hearing loss [16]. A person presenting with hearing loss should be thoroughly examined and investigated. Hearing thresholds assessment will help to determine the type of hearing loss, whether it is sensorineural, conductive or mixed hearing loss. Also, hearing thresholds assessment will help to determine the severity of the hearing loss. All these will help to determine those that will need hearing aid. Options in managing hearing loss include cochlear transplant [17] and hearing aid [18].

Any form of intervention that will improve the hearing function of the affected person will improve his inter-personal interaction and will mitigate stigmatization. However, some of the challenges faced in the rehabilitation of people living with hearing loss are that hearing aids are expensive and cochlear transplant surgery is also expensive and the patient may not be able to afford the cost of treatment.

Cleft palate and cleft lip are developmental anomalies that result from incomplete closure of the facial structures. Cleft lip/palate can occur in isolation. Cleft palate has also been found to occur in association with hearing loss is some disease conditions such as Stickler syndrome (hereditary progressive arthro-ophthalmopathy), Treacher Collins Syndrome, Smith-Lemli-Opitz syndrome and Genitopatellar syndrome.

The primary function of the palate is to demarcate the oral cavity from the nasal cavity. In cleft palate, the demarcation is breached resulting in nasal regurgitation and feeding difficulty [19]. Also sleep-disordered breathing including obstructive sleep apnea can occur in patients with cleft palate [20].

Speech disorders are common in cleft palate [21]. The affected person may have poor speech as well as nasal speech. The disfigured face caused by the cleft palate and cleft lip as well as the poor speech contributes to the stigma found among these individuals. The stigma in orofacial cleft affects not only the afflicted but also the family of the afflicted person [22]. A study showed that many parents were ignorant as to the exact cause of orofacial cleft and seventy-three percent of the mothers were ashamed to have children with cleft palate and cleft lip [22]. The family of the afflicted child felt stigmatized by their neighbours some of who refused to touch the child [22].

Cleft palate is amenable to surgery, but the surgery is expensive and the patient may not be able to afford it.

Ebola virus disease and Lassa fever belong to the group of diseases that is referred to as viral haemorrhagic fevers [23]. Viral haemorrhagic fevers are caused by viruses. Ebola virus diseaseor Ebola haemorrhagic fever is caused by Ebola virus while Lassa fever is caused by Lassa virus [23].

Infection by Ebola virus or Lassa virusinitially leads to non-specific febrile illness although it may be asymptomatic in some cases [23] [24] [25]. The infection may progress to severe illness with multiple organ failure and death. For Lassa fever, Ribavirin is the antiviral agent of choice while for Ebola virus disease; there is no specific antiviral agent [23]. Supportive care is very important in all symptomatic cases of viral haemorrhagic fevers. Coagulopathy and bleeding are remarkable features of viral haemorrhagic fevers.

Treatment and nursing of viral haemorrhagic fever patients involve the use of personal protective equipment (PPE) [23]. Viral haemorrhagic fevers are deadly and very infectious. Because of this, there are special and standard protocols for handling the bodies of people who died from the disease. The dead body is usually put in double body bags and buried by government officials.

The high infectivity and high mortality rate of viral haemorrhagic fevers make them to be dreaded and stigma-associated. Even health care workers and care-givers are scared of contracting viral haemorrhagic fever and dying from it. This is coupled with the fact that the body of the dead patient is not released to the relatives for burial. This is a very important issue among some tribes such as the Igbos of Nigeria which has the culture of according a special and decent burial to their dead relatives.

Stigma in viral haemorrhagic fever can persist even after the patient has recovered from the acute illness [26].

There are different types of sexually transmitted diseases and they include gonorrhea, syphilis, genital herpes, trichomoniasis, granulomainguinale (Donovanosis), lymphogranuloma venereum, and human immunodeficiency virus infection [27]. Even before the emergence of human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS), sexually transmitted diseases (STDs) are associated with stigma because STDs are associated with promiscuity and immoral behavior. In HIV/AIDS, the stigma associated with sexually transmitted diseases is even more pronounced. In addition to the social stigma, persons living with HIV/AIDS also feel stigmatized by the healthcare professionals because of the extra measures these professionals may take when taking care of them in the hospital [28].

A person with HIV/AIDS will develop a feeling of guilt and regret and may not have the courage to declare his illness and visit the hospital for treatment early enough. The affected person may even be in a state of denial initially making him not go for treatment on time. When people around him find out the nature of his illness, they may deride him and subject him to social discrimination. Due to stigma and depression, suicidal thoughts were found to be common among people living with HIV/AIDS in Nigeria [29].

Some of the sexually transmitted diseases are treatable [27]. Although, there is currently no cure for HIV/AIDS, treatment can significantly reduce the morbidity associated with the disease and also prolong the life of the affected person.

In HIV/AIDS, the associated stigma can be mitigated by getting the society to be more tolerant with persons living with HIV/AIDS and also by helping the affected persons to cope with the disease [30].

Just like leprosy, epilepsy is another stigma-associated disease that was mentioned in the Holy Bible [31] [32] [33]. Epilepsy is a chronic neurological disorder which in its classical form manifests with seizures. When the affected person has generalized seizures with loss of consciousness, it may look terrifying to the onlookers [31] [33].

Epilepsy can be caused by a wide range of things such as trauma to the head, stroke, developmental anomaly, infections and tumor. In some cases, no cause can be found. Special laboratory investigations for epilepsy include electroencephalography to determine the nature of the abnormal electrical activities of the brain and brain imaging, preferably, magnetic resonance imaging (MRI) to see if there is any structural abnormality such as brain tumour or cerebral infarction.

The seizures can be controlled with anticonvulsants and several anticonvulsants are available to choose from. [34]. Where a cause exists as in the case of brain tumour, the cause should be treated. Some cases of epilepsy will require treatment for life.

Epilepsy is associated with stigma [35]. In Nigeria, the burden of stigma associated with epilepsy has been found to be very high [36]. The affected person is more likely to feel stigmatized if his epileptic attack occurs in public, i.e., if an outsider gets to know that he is living with epilepsy [36]. The stigma associated with epilepsy arose from misconception and misunderstanding of the disease [4]. In the bible, epilepsy was thought to be caused by evil spirit [3] [32] [33]. The stigma in a person that is living with epilepsy gives him a feeling of shame, rejection and loneliness [35]. In Nigeria for example among Igbos, nobody will like to marry a person living with epilepsy.

People with mental ill-health or poor mental health are those with mental or behavioural disorders. They include those with bipolar disorder, mania, depression, dementia, schizophrenia, anxiety disorder, post-traumatic stress disorder (PTSD), substance abuse and suicidal behaviour disorder [37] as well as those with retarded mental development and degenerative central nervous system disease. People with mental ill-health or poor mental health are among the most stigmatized.

Because of the wide and varied nature of mental health problems and their aetiological factors, a wide range of therapists are involved in the management of the medical, psychological and social challenges posed by these clinical problems. They include physicians, psychiatrists, clinical psychologists, medical social workers, occupational therapists, sociologists, clergies and even herbalists.

A psychotic individual is presumed to be dangerous and unpredictable [38]. This is part of what fuels prejudice, antagonism and social segregation against such mentally ill individuals. In the Middle Ages, the mentally ill were imprisoned, burnt or killed [38]. At the present time, some cultures still encourage the chaining and flogging of the mentally ill especially if he is considered to be violent, a condition which ordinarily would require a major tranquilizer. Because most psychotic illnesses run a chronic cause, the associated stigma is a life-long challenge.

Suicide is defined in the Merriam-Webster dictionary as “the act or an instance of taking one’s own life voluntarily and intentionally” [39]. Attempted suicide is when someone attempted and failed to end his/her life. Suicidal ideations, “often called suicidal thoughts or ideas, is a broad term used to describe a range of contemplations, wishes, and preoccupations with death and suicide” [40].

Globally the suicide rate is high, about 700,000 per year [41]. Traditional suicide method used to be by hanging, but now self-poisoning and shooting oneself are other common methods of committing suicide. The new trend which is very worrisome is that when some people want to commit suicide, they will kill their wives and children before killing themselves. This trend is currently observed in the United States of America. “Many suicides happen impulsively in moments of crisis with a breakdown in the ability to deal with life stresses, such as financial problems, relationship break-up or chronic pain and illness” [41].

Suicide impacts negatively on the affected person, his family, his community and his country. In some African culture, suicide is considered to be a very strong taboo. In Igbo culture, when somebody hangs himself in a forest, his family will pay an herbalist to bring down the body and have it buried in the forest. Afterwards the family will say that the person is missing rather than admit that he has committed suicide. This is an attempt to get the stigma of suicide off the family. This is an example of stigma operating at the family level. The challenges that are posed by suicide require a multidisciplinary approach involving physicians, psychiatrists, clinical psychologists, medical social workers, sociologists and clergies.

Suicide is a big problem among patients with depression. Both mental illness and suicide are associated with stigma.