A 24-year-old man, graduate in Banking and Insurance, jobless, single, without children was admitted in the Department of Cardiology and Internal Medicine of the University Hospital of Brazzaville for a sudden onset syncope, associated with an unstated fever, evolving for about a month. The sudden onset fever with chills and sweating had been treated on an outpatient basis with anti-malaria, then antibiotics. The patient reported one week before admission, palpitations, two episodes of puncture syncope and arthromyalgia.

On admission temperature was 39˚C and the respiratory rate was 16 cycles/min. The heart rate was 40 beats/min, the BP 120/70 mm Hg. Cardiac auscultation showed a diastolic murmur of 2/6th aortic failure. The pleuropulmonary examination was normal. Hackett’s type 2 splenomegaly was noted.

The frontal chest X-ray showed a heart of normal volume (CTR = 50%), the lungs, pleura and pulmonary vascularization were also normal. The electrocardiogram (ECG) showed bradycardia at 34 beats/min, complete atrioventricular block (AVB), (Figure 1).

Two-dimensional transthoracic echocardiography coupled with Doppler revealed: thickened aortic sigmoid, absence of vegetations, a left ventricle of normal size, a left ventricular ejection fraction (LVEF) at 71%, an aortic peri-annular abscess and two septate abscesses of the interventricular septum (Figure 2 and Figure 3).

The aortic insufficiency was grade 2 on pulsed Döppler. The mitral profile was of the relaxation disorder type. Pulmonary artery pressure (PAP) was normal.

The biological assessment revealed: two negative blood cultures, a negative retroviral serology (HIV), a C-reactive protein (CRP) at 24 mg/l and a sedimentation rate at 90 mm, a leukocytosis at 12,000 elements/mm³. Hemoglobin was 12.1 g/dl, platelets 200,000 cells/mm³, and fasting blood sugar was 0.81 g/l. The urine cytobacteriologic examination (ECBU) was sterile.

The diagnosis of infectious aortic endocarditis on a native valve complicated by peri-annular and septal abscess was suggested and retained according to Duke’s criteria. A complete syncopal AVB was associated.

The medical treatment combined: a sodium-reduced diet, dual antibiotic therapy (ceftriaxone 3 g/day for six weeks, and gentamycin 160 mg/day for two weeks), a converting enzyme inhibitor (Enalapril 10 mg/day). Bacteriological control of the infection at the end of treatment was not possible. Cardiac surgery was urgently chosen for the removal of the abscesses and the installation of a permanent pacemaker.

Due to insufficient technical facilities, and taking advantage of family reunification, subsequent care was provided in South Africa. It consisted of surgery under cardiopulmonary bypass to flatten the abscesses a month and a half after discharge. Six weeks later, a Biotronik brand single chamber pacemaker was fitted.

The frontal chest x-ray taken postoperatively (Figure 4) showed the pacemaker and the endocavitary stimulation probe.

The follow-up ECG one year after pacemaker insertion showed regular electro systolic training (Figure 5).

At the check-up on August 5, 2021, the patient was asymptomatic and in good hemodynamic condition. The heart rate was regular and the cardiac auscultation was normal.

The 08/05/2021 check-up ECG (Figure 6) showed sinus rhythm, complete Left bundle block and no spike.

The echocardiogram of 05/08/2021 (Figure 7) showed undilated cardiac chambers and the pulsed Doppler objectified grade 1 or 2 aortic insufficiency. The medical treatment based on enalapril, is continued to this day.

A 28-year-old patient, single, without children, uneducated and unemployed,

residing in Brazzaville, referred to the department of Cardiology and Internal Medicine of the University Hospital of Brazzaville for an infectious endocarditis.

No history of chronic inflammatory disease, recurrent angina and polyarthralgia in childhood has been noted. The patient was neither hypertensive nor diabetic. He neither consumed alcoholic beverages nor smoked.

Symptoms dated to about five weeks before admission with the gradual onset of NYHA stage II exertional dyspnea that progressed to NYHA stage IV resting dyspnea. It was associated with an oscillating fever with peaks at 40˚C, chills and a fatty cough bringing back foamy sputum.

These symptoms prompted a visit to a local clinic, where the diagnosis of infectious endocarditis complicated by aortic abscess and heart failure was made. A treatment included a dual antibiotic therapy based on ceftriaxone 3 g/day and gentamycin 160 mg/day combined with captopril 25 mg × 2/day and furosemide 40 mg/day parenterally was administered.

The persistence of the clinical presentation required a consultation twelve days later at the Emergency Department of the University Hospital of Brazzaville, then his admission to the department of cardiology.

The vital signs at the entry were: a respiratory rate at 40 cycles/min, an oxygen saturation at 98% in ambient air, a weight of 42 kg (previous weight 70 kg, that is to say a loss of 28 kg), a height of 1.68 cm, BMI = 14.88 Kg/m², a temperature at 40˚C and a BP at 120/60 mm Hg.

The rest of the examination showed a chest of normal configuration, well-perceived heart sounds, a regular heart rate at 40 beats/min, a diastolic murmur of 3/6 aortic insufficiency and the absence of pericardial friction. The patient presented with bilateral crackling rales, hepatomegaly with a hepatic arrow at 16 cm, lower-extremity edema, painless and keeping the cup. The skin and appendage examination was normal.

The oropharyngeal examination revealed: tartar, multiple decayed teeth 47-21-11-26 (chicot), 14 - 17 (dilapidated) and cervical caries of the 42. The infectious port of entry was dental. The ENT examination and the other organs were normal.

The chest x-ray (Figure 8) showed significant cardiomegaly (CTR = 70%), venous redistribution towards the peaks, capillary venous hypertension, absence of pleural effusion.

The ECG, Figure 9 showed bradycardia at 42 beats/min related to a 2nd degree AVB, type 2 from MOBITZ.

Two-dimensional trans-thoracic cardiac ultrasound coupled with Doppler revealed a 68% left ventricular ejection fraction (LVEF), dilated left cardiac chambers, the presence of three empty echo images at the expense of the basal septum extending to the base of the aortic cusps interfering with their opening. Partitioned abscesses were mentioned. The aortic insufficiency was grade 2 on doppler. PAP was normal. The wall thicknesses were normal, the pericardium free and the inferior vena cava dilated.

The interventricular (SIV) septum abscess is shown in Figure 10.

- Laboratory examinations noted: two negative blood cultures, negative retroviral (HIV) serology, CRP at 63.14 mg/l, ESR at 45 mm, leucocytes at 11,000 elements/mm³. The hemoglobin level was 11.7 g/dl, the platelets at 20.0000 elements/mm³ and the fasting blood sugar level at 0.81 g/l.

- The diagnosis retained was an infectious aortic endocarditis on native valve with a global heart failure, septal abscesses, a 2nd degree AVB type 2 of MOBITZ.

- The medical treatment included: the sodium-reduced diet, a bi-antibiotic therapy ceftriaxone 3 g/day for six weeks and gentamycin 160 mg/day for two weeks, captopril 50 mg/day, furosemide 40 mg/day parenterally. The additional treatment was stomatological, consisting of: twice daily mouthwashes, scaling, dental extractions associated with the administration of antibiotics based on: amoxicillin and clavulanic acid 3 g/day, metronidazole 1.5 g/day.

- The course was marked by thermal defervescence and regression of signs of heart failure.

Due to the inadequacy of the technical platform, a medical evacuation was chosen, for the performance of emergency cardiac surgery in order to flatten the abscesses, and to proceed with an aortic valve replacement and a pacemaker installation. in case of worsening of the AVB.

Maintenance therapy included: captopril 100 mg/day; furosemide 20 mg/day; bricanyl LP 10 mg/day. A monthly check-up at CHU-B was recommended, pending patient management. The outcome at one year was favorable (good hemodynamic condition, return to sinus rhythm).

It was about a 25-year-old patient, referred to the cardiology and internal medicine department of the University Hospital of Brazzaville for the treatment of infectious endocarditis, after probabilistic biantibiotics at a city clinic for two weeks.

Symptoms began three weeks before her admission with the progressive onset of exertional dyspnea classified as stage II by the NYHA, which became stage IV in a febrile context. It was associated with palpitations, chills, altered general condition and a dry cough.

On admission, the patient presented: polypnea (FR = 32 cycles/min), oxygen saturation at 99% in ambient air, a weight of 52 kg (previous weight 60 kg, i.e. a loss of 8 kg), a height of 1.70 cm. The temperature was 38.6˚C and the BP 120/70 mmHg.

The remainder of the examination noted: a normal chest configuration, well-perceived and regular heart sounds, tachycardia at 105 beats/min, and proto-diastolic galloping noise. Note the absence of pericardial friction and splenomegaly.

- The chest X-ray (Figure 11) showed significant cardiomegaly, a cardio-thoracic ratio (RCT = 66%), and venous redistribution towards the peaks. Free diaphragmatic and cardio-phrenic costo sac culverts.

The EKG showed sinus tachycardia at 100 beats per minute.

The 2D trans-thoracic cardiac ultrasound (Figure 11) coupled with Doppler revealed a moderately dilated left ventricle (ejection fraction: 51%). The other aspects noted were: a heterogeneous intramural mass at the junction of the posterior wall of the left ventricle and the left atrium measuring 51 mm in diameter, two abscesses of the interventricular septum measuring 12 mm in diameter. The

mitral profile was restrictive, and PAP was normal.

- Laboratory examinations made it possible to note: two negative blood cultures, negative retroviral (HIV) serology, CRP at 105 mg/l; a VS at 60 mm. Leukocytes were 12,800 cells/mm³, hemoglobin 12.1 g/dl, platelets 202,000/mm³, and fasting blood sugar 0.71 g/l. The serum creatinine was 11 mg/l.

The intramural mass noted on cardiac ultrasound (Figure 12) was explored by a chest CT scan with and without injection was performed (Figure 13 and Figure 14).

The diagnosis of infectious aortic endocarditis involving a native valve complicated by septal abscess and heart failure was retained. An intramural mass of the left heart was associated.

The medical treatment included: a sodium-reduced diet, digoxin 0.25 mg/day, captopril 25 mg 1 tablet × 2/day, intravenous furosemide 20 mg × 2/day.

The course was marked by persistent fever and regression of signs of heart failure.

Due to insufficient technical facilities, medical evacuation abroad was selected.

The length of hospitalization was 16 days in addition to the two weeks stay in a private clinic. At the two-year check-up, the patient’s condition remains stable hemodynamically and rhythmically. Adherence to maintenance cardiological treatment is good.

The other lesions observed were: HF and abscesses.

- It is accepted that heart failure is the main complication of infectious endocarditis occurring on a native valve, especially the aortic valve, because the course is more prolonged in these endocarditis [12] [15]. Two of our patients had presented with HF.

TTE visualized: SIV abscesses (consistently); an annular abscess (in one case). In any case, no valve vegetation was visualized. ETO would have been of great help. In mitro-aortic insufficiency, a cardiac tumor of the posterior wall of the heart was associated. She was atrial and ventricular, heterogeneous on TTE, and exhibiting both a liquid and a solid component on the chest CT scan with injection.

- Two cases of atrioventricular conduction disorder were observed. In the literature [29], atrioventricular blocks secondary to septal abscesses generally complicate infectious endocarditis in 2% to 4% of cases. Other authors like Meine et al., [30] have noted higher rates: 26% of conduction abnormalities. These were BAV III, BAV II and BAV I, in a series of 137 cases of infectious endocarditis. Out of 15 cases of abscessed infectious endocarditis, eight cases of AVB were noted in a recent series [31]. High rates of conduction disturbance have also been reported by Choussat et al. [32]. From 233 cardiac abscesses, 20 cases of high degree AVB (II or III) only on aortic abscess were observed. Conduction abnormalities appear to be much more frequent and severe in abscessed endocarditis, especially in the presence of peri-aortic and septal abscesses. These irritate or compress the atrioventricular conduction pathways.

On the other hand, this finding is not always so clear, Danchin et al. [33] compared the evolutionary profile of 122 cases of infectious endocarditis with and without abscess of the aortic annulus and did not note any difference in the occurrence of atrioventricular conductive disorders.

The therapeutic approach for infectious endocarditis is multidisciplinary involving, among others, the cardiologist, the microbiologist, the infectious disease specialist and the surgeon. In our study, medical treatment reduced the signs of HF without, however, solving the problem of the infectious focus which required urgent surgery. However, the infectious syndrome was persistent. In view of this, surgery would have made it possible to put an end to the infectious process by flattening the abscesses, to restore the integrity of the atrioventricular conduction by the pause of a pacemaker and to set up an aortic valve replacement by an aortic valve. mechanical or biological prosthesis. Only one patient was operated. This therapeutic approach is described in the literature and it alone allows definitive cure of IE [29] [34] [35].