Severe hypertriglyceridemia can be potentially fatal condition that can have primary and secondary causes. Triglyceride levels above the 95^th percentile for age and sex define hypertriglyceridemia [1] [2] [3] [4]. Hypertriglyceridemia can be mild to borderline high (150 - 199 mg/dl), moderate to high (200 - 499 mg/dl), very high (500 - 999 mg/dl), severe (1000 - 1999 mg/dl) and very severe (>2000 mg/dl) [5] [6] [7] [8] Primary hypertriglyceridemia is due to a genetic defect. Secondary hypertriglyceridemia in children can be associated with kidney disease, endocrine disorder, immunological disorder, lifestyle (e.g. eating high-fat diet) and medication [9]. Prevalence of hypertriglyceridemia in infants is quite limited more specifically in developing countries, however, in developed countries like in United States (US), approximately 20 percent of children (age 6 to 19 years) have adverse levels of one or more lipid values, of which 10.2 percent have elevated TG of (≥130 mg/dl [1.5 mmol/l]) [10]. Hypertriglyceridemia if remain undiagnosed and treated can result in pancreatitis, lipemia retinal, coronary heart disease and death [11] [12]. Management is still challenging in underdeveloped countries due to the interplay of genetic and secondary causes as well as the lack of evidence-based guidelines [11]. Therefore treatment primarily focuses on promoting healthy eating habits and encouraging weight loss for those who are obese rather than treating the triglyceride (TG) valueper se. In infants, lifestyle modification can be hard to implement, therefore prompt medical intervention is the choice of treatment. Otherwise severely elevated TG levels (i.e., a single TG level > 2000 mg/dl) or persistent Triglyceride levels > 500 mg/dl (5.6 mmol/l) can lead to complication and therefore pharmacologic treatment in this setting may be warranted to prevent these complications.

Here we present a case of 1 month and 3 weeks old baby with skinny strawberry yoghurt like blood.

Was admitted at the age of 1 month and 3 weeks, as referral from nearby health centre, presenting with difficulty in breathing for 3 days, sudden onset associated with grunting and chest wall in drawing, was also accompanied with poor feeding, and irritability with no history of convulsion. At the heath centre the patient received Ceftriaxone injection, Hydrocortisone and oxygen therapy. On arrival the child had a Temperature of 36.4, pulse rate of 137 beats/minute, and respiratory rate of 64 breath/minute, saturating at 73% on room air and 95% on oxygen 2 litres via nasal prongs.

The baby was delivered at term with weight of 4 kg, without any complication or prior history of admission and was firstborn to the parents with a positive history of hypertension in the maternal side (grandmother of a child).

Examination findings: Well-nourished, ill-looking, distressed on oxygen, mild pale, not cyanosed, not jaundiced, and had vitals T of 36.5˚C, pulse rate of 152 B/min, RR of 61 B/min.

Respiratory system examination had chest wall in drawing, with fine bilateral crackles, otherwise, on cardiovascular system, skin examination, abdominal examination and neurological examination were all normal.

Incidental finding: During sample collection the blood was noted to be strawberry yoghurt like, this prompted multiple venepuncture thinking the child had localized Puss collection, but even with change of area, the sample collected was the same (Figure 1).

Diagnosis and management: Had initial working diagnosis of severe pneumonia, hyperlipidaemia and differential diagnosis of chylomicronemia. The child was initiated on IV Ampiclox and Gentamicin, kept on oxygen therapy, and laboratory investigation were taken.

Investigation results: His initial full blood picture, the lab technician could not analyse the haemoglobin due to sample being too lipemic, otherwise this results showed leucocytosis of 21 × 10⁹/l, with neutrophil predominant of 49%, haematocrit of 15.6%, thrombocytosis of 547 × 10⁹/l (Figure 3). After dilution of the sample with normal saline at 1:1 of which showed leukocyte count of 14.83 × 10⁹/l, haemoglobin of 19.3 g/dl, and platelets of 385 × 10⁹/l haematocrit of 17.2%

Her biochemistry profile showed a serum sodium level of 87 mmol/l, potassium of 3.2 mmol/l, urea of 3.1 mmol/l, serum creatinine of 40 µmol/l, triglyceride of 136 mmol/l (12,046 mg/dl), total cholesterol of 43 mmol/l (1662 gm/dl), HDL of 6 mmol/l (232 gm/dl) and amylase of 20 U/l. Having normal TSH of 2.43 µIU/ml and T4 of 125.8 ng/ml, serology for HIV was negative and blood culture was negative as well.

Chest x ray had features suggestive of lobar pneumonia with increase in cardiac silhouette(X ray was supine) (Figure 2). After the investigations our working diagnosis was Severe Pneumonia, Electrolyte imbalance (hyponatremia and hypokalaemia) and Infantile Hypertriglyceridemia

Discharge and follow up: The child was to continue with antibiotics above, electrolyte correction of hyponatremia with 3% Sodium Chloride, as well as Potassium Chloride, and was started on Rosuvastatin 5 mg orally daily dose.

6^th day the child was off oxygen, she was discharged 8^th day after completing antibiotics with Rosuvastatin at the same dose, then scheduled to be seen as outpatient every month in our clinic, monitoring lipid profile in every visit.

The trend of lipid control as shown below (Table 1 and Figures 1-4):

WHO report shows increase in number of overweight children under five years by nearly 24% percent since 2000. Due to association with increase in epidemic of obesity hyperlipidaemia is an increasing prevalent risk factor in children. Familial hypocholesteraemia syndrome usually present in childhood, but few cases about 25% has been found to manifest during infancy [9]. There has been several cases reported from India, in very young children aged between less than a month and 2 month. Some presented with non-related clinical features such as bacterial infection with systemic complications such as acute renal failure and completely recovered. The diagnosis was clinical and genetic testing was not available [13]. This is similar to our patient who was diagnosed at 42 days of life and we also failed to do any advanced testing due financial constraints and limited resources. Most cases of lipid disorders are asymptomatic, even selective screening (i.e., screening only children with a positive family history) fail to identify a significant number of children with lipid disorders [14].

Paediatric lipid disorders often track into adulthood. Approximately 50% of children with abnormal serum lipoprotein values continue to have elevated lipid levels in adulthood [4] [15] [16] and [17]. Children with severely elevated lipid values consistent with familial hyperlipidaemia show stronger tracking to adulthood. Cumulative exposure to dyslipidaemia appears to be associated with cardiovascular risk later in life.

Pharmacological options for children with high triglyceride are limited, so most of interventions are non-pharmacological like diet modification, the use of fish oil, increased physical activity, and weight loss. Children with Triglyceride (TG) levels between 150 mg/dl (1.7 mmol/l) and 399 mg/dl (4.5 mmol/l) and a non-high-density lipoprotein cholesterol (non-HDL-C) ≥ 145 mg/dl (3.7 mmol/l) may need pharmacology if other non-pharmacological treatment are unsuccessful. In our patient, diet and lifestyle modification were not feasible due to the young age so we opted for pharmacological intervention.

Although fibric acid derivatives e.g. gemfibrozil, fenofibrate are highly recommended in treatment of hypertriglyceridemia due to less side effect and being well tolerated in children, studies have shown triglyceride levels decreased with the use of fibrates, did not change when the statins were used, but found to increase when bile acid-binding resins were used e.g. cholestyramine [18]. Other studies also have suggested statins to be more effective with lowering the cholesterol than lowering triglyceride level [19] [20]. In our case, the child showed response to statin. The choice of medication was based on availability, family economic status, e.g. in out setting most common available lipid lowering drugs are statins, which prompted to be the first pharmacological option for the patient.

Lipid lowering drug (statins) and exclusive breast feeding dramatically improved lipid parameters to our patient without any reported adverse effect on follow-up. Although the cases of hypertriglyceridemia are rare, this also proves a role of statins in treatment of hypertriglyceridemia in low resource setting were the first line drugs like fibric derivatives are not available.

We report a case of infantile hypertriglyceridemia found accidentally during phlebotomy. Despite limited resource to evaluate further on primary cause of this condition as well as family’s poor economic status to seek further medical evaluation outside the country, this case report raises awareness on how to deal with this condition. It also highlights the role of statins in the treatment of hypertriglyceridemia.

Verbal informed consent was obtained from the patient’s mother for publication of this case report.

MM, DNM, FM, AS conceptualised and prepared the manuscript PEM; PM, ERM, EK, AL, ZH, IM, NP, AI, LF, FM, RM, BM, LK and MJ reviewed the patient medical records. This manuscript has been read and approved by all authors.

The authors declare no conflicts of interest regarding the publication of this paper.

Mselle, M., Shayo, A., Mbwasi, R., Mosha, F., Pyuza, J., Mrindoko, P., Peter, N., Meleki, E., Kimambo, E., Likiliwike, A., Frisch, L., Swai, M., Hatibu, Z., Iman, A., Maringo, B., Kissila, L., Minga, I. and Mchaile, D. (2021) Rare Case of Surviving Infant with Strawberry Yoghurt like Blood Diagnosed to Be Infantile Hypertriglyceridemia at 1 Month Old: A Case Report. Open Journal of Pediatrics, 11, 777-785. https://doi.org/10.4236/ojped.2021.114072

TG triglyceride

LDH low density lipoprotein

IV intravenous

TSH thyroid stimulating hormone