This is a descriptive and transversal study. It relates the use of medical prescriptions received in pharmacies in the department of Dakar.

The study population is the drugstores located in the department of Dakar.

· Inclusion Criteria

Are selected all the prescriptions in the right form, i.e. the prescriptions where the date, the name of the patient, his weight if it is a child, the stamp and signature of the doctor and the products which must be delivered to the patient are present.

· Criteria for non-inclusion

Any non-conforming prescription, i.e. without any possibility of identifying the prescriber, the patient or both.

The study took place from December 1, 2016 to June 30, 2017, i.e. a duration of 7 months.

Dakar department is divided into 19 municipalities of districts to which a number has been assigned. A drawing of lots was carried out to determine the 7 communes, i.e. one third, which will be visited. The survey was conducted in 90 pharmacies in these municipalities, which represent one third of the 270 pharmacies in the department of Dakar.

· Contact with pharmacy managers

A letter was sent to all the drugstore managers who were targeted for our survey. Dates and times for the survey were agreed upon with the managers of targeted drugstores.

· Composition of the survey team, calibration and pre-investigation

Five pharmacy thesis year students from different pharmacies were part of the investigation team. Training sessions were organized to ensure that all the investigators were calibrated in order to standardize the data collection. A pre-investigation of two pharmacies was carried out in order to identify difficulties or misunderstandings and to correct them before the final survey.

· Prescribers: Specialists who prescribe drugs

· Dosage: Report the dosage of each product if determined;

· Duration of treatment: Report the duration of each treatment if indicated;

· Patient’s age, weight and gender.

Survey teams spent a week in each targeted drugstore for 3 half-days.

Results have been analyzed with epi info version 6.04 and Excel.

· Notification on duration of treatment

More than half of prescribers (63.90%) did not give any written information to patients regarding the duration of treatment. This could create a problem especially since often in our African context illiterate patient could afford to renew the treatment or even stop it before the end of the medication or as soon as the symptoms disappear. Doctors must specify if the drug is to be renewed and how

many times, specifying the exact duration of the drug’s use. It would also be important for the doctor to inform the patient that the drug prescription given to him or her cannot be applied to another person. Indeed, in our African context, the patient often advises his or her relatives to take the same drugs if he or she seems to be developing the same symptoms. Diop et al.’s study reveals that 37% of households use traditional medicines and 32% self-medicate for dental pain [4]. In addition, the pathology treated, patient’s condition and disease history are the main factors on which the doctor will base his prescriptions. In all cases, it should be specified, as the absence of an indication of the duration of the treatment most often leads to non-compliance with the treatment. According to Sondo, the main errors observed in prescribing are: failure to mention the duration of treatment, posology, galenic form, drug dosage or inadequate mention of the drugs [2]. Most prescriptions are valid for three months. Prescriptions are generally renewable for periods of up to one or three months. Contraceptives are renewable for one renewal per three-month period [1].

Drugs appear to be expensive in Senegal. The cost of the drugs is affordable, while the remaining 49.5% of the population describes them as expensive. This does not encourage patients to renew their treatment. Failure to renew treatment can lead to resistance to certain drugs and, above all, to therapeutic failure [5].

Treatment duration is higher for neurologists, urologists, gynaecologists, diabetologists and rheumatologists with 120 days, 90 days, 69 days, 60 days and 51.1 days respectively. Neurological diseases are generally long-term conditions, which makes treatment longer. The acceptance of treatment by patients was an issue raised by some participants, especially among depressed patients [6].

However, respecting the criteria of the depression practice guidelines can reduce drug costs. But 5.39% of prescriptions only carry the mention “to be renewed”. We found that all diseases with an average duration of more than 30 days require the renewal of the medication. Therefore, François and Bosson link the quality of the prescription to the use of a software program for entering drug prescriptions [7] [8].

The most commonly reported problems regarding the application of e-prescriptions were found to be system-induced problems (26.5%) and internet problems (19.9%) [9].

The same is true for diabetes, which is a chronic disease. The duration of treatment certainly plays an important role and the management of a chronic disease is much more difficult for patients for two main reasons: tiredness and a lack of perception of the beneficial impact of treatment [10].

In gynaecology, treatments are generally not very long in case of infection. Ovules are used for an average of one week and the use of antibiotics, if necessary, can be extended to three weeks for some protocols [11]. Treatments can be much longer in the case of sterility.

In urology, female cystitis: initial cystitis and its treatment with a single dose or with fluoroquinolones (3 days) is the shortest treatment [12]. The treatment can be long as in men in case of prostatitis. The prevalence of prostatitis ranges from 5% - 9% in the general population and it is estimated that 50% of men will develop prostatic disease at some point in their lives [13]. Cytobacteriological examination of the urines reveals urinary tract infections in 48% to 71% of cases resulting in a treatment duration of four to six weeks [14]. In case of persistent symptoms, treatment should be extended for six to 12 weeks [15].

However, it is important to improve access to antibiotics for therapeutic purposes while minimizing the overuse of antibiotics that causes problems in the resistant population [16]. Antibiotic overuse is illustrated by the study by Pouwels et al which found that of the 931,015 included consultations that resulted in an antibiotic prescription, approximately 1.3 million days exceeded the recommended guideline [17].

In rheumatology, treatment can be long as in rheumatoid arthritis. The clinical efficacy of combination therapies, even in the absence of biotherapy, begins at six months and continues at twelve, eighteen and twenty-four months [18]. The characteristics of the disease may also influence treatment compliance. It is evident that adherence to the treatment will be better if the patient can immediately verify the beneficial effects of the treatment (thanks to the pain elimination in the case of an algic pathology). In the case of dental diseases, for example, the duration of treatment varies from 3 to 6 days according to our study. the study was to evaluate the appropriateness of antibiotics prescriptions by Lebanese dentists to patients with endodontic abscesses and their compliance with the guidelines show that antibiotics were also prescribed unnecessarily to 17/42 patients with a chronic endodontic abscess [19].

However, the duration of the treatment depends on the type of pathology. In the case of chronic diseases, the treatment can be extended, and this requires a follow-up for good compliance [20], but this long-term prescription must take into account secondary effects [21].

Diouf et al. study showed that 83.5% of dentists reported having experienced at least one case of undesirable effects during their practice. Antibiotics remain the drug class most associated with the occurrence of these undesirable effects [22].

In the end, good prescribing is important. According to the study by Krishnapillai et al., the evaluation of 9199 prescriptions from 344 physicians showed that about 37.2% (95% CI: 34.9% - 39.4%) of the prescriptions were of good quality, and 48.2% (95% CI: 42.9% - 53.7%) of the physicians provided quality prescriptions. Factors associated with prescription quality were knowledge of NCD guidelines, hospital quality certifications and use of patient data management software [23].

However, some limits of the study are the inclusion of drugs sold in health structures (Bamako Initiative), would have allowed us to better assess and give more reliable results regarding prescriptions in general. More so as prescription of generic drugs plays an important role in accessing health care [24].