<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">ABC</journal-id><journal-title-group><journal-title>Advances in Biological Chemistry</journal-title></journal-title-group><issn pub-type="epub">2162-2183</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/abc.2021.111002</article-id><article-id pub-id-type="publisher-id">ABC-107017</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Chemistry&amp;Materials Science</subject></subj-group></article-categories><title-group><article-title>
 
 
  Central Role of Innate B-Cell Immunity in Cancer Prevention
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Nikolay</surname><given-names>Tupitsyn</given-names></name><xref ref-type="aff" rid="aff1"><sub>1</sub></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Federal State Budgetary Institute “N. N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of Rus-sia, Moscow, Russia</addr-line></aff><pub-date pub-type="epub"><day>13</day><month>01</month><year>2021</year></pub-date><volume>11</volume><issue>01</issue><fpage>12</fpage><lpage>14</lpage><history><date date-type="received"><day>28,</day>	<month>May</month>	<year>2020</year></date><date date-type="rev-recd"><day>30,</day>	<month>January</month>	<year>2021</year>	</date><date date-type="accepted"><day>2,</day>	<month>February</month>	<year>2021</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  There are some forgotten items. There is 
  a 
  specific way to eradicate cancer
   cells at the very early stage of their appearance. Natural humoral immunity with CD5+ B-cell produced pentameric IgM to cancer associated glycans normally 
  to 
  eliminate arising cancer cells. This branch of innate immunity is decreasing with age and that is a basis for selective immunodeficieny which may be corrected. This area of research was well studied and proved by the team of Prof. Vollmers (Germany), but then forgotten for about 15 years.
 
</p></abstract><kwd-group><kwd>Natural B-Cell Immunity</kwd><kwd> Cancer Prevention</kwd><kwd> IgM</kwd><kwd> Anti-Glycans</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>Conflicts of Interest</title><p>The author declares no conflicts of interest regarding the publication of this paper.</p></sec><sec id="s2"><title>Cite this paper</title><p>Tupitsyn, N. (2021) Central Role of Innate B-Cell Immunity in Cancer Prevention. Advances in Biological Chemistry, 11, 12-14. https://doi.org/10.4236/abc.2021.111002</p></sec></body><back><ref-list><title>References</title><ref id="scirp.107017-ref1"><label>1</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Davydov</surname><given-names> M.I. </given-names></name>,<etal>et al</etal>. (<year>2017</year>)<article-title>There is No Cancer Immunology, It is Mere Infectional Immunology</article-title><source> Haematopoiesis Immunology</source><volume> 15</volume>,<fpage> 10</fpage>-<lpage>11</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.107017-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Brandlein, S., Pohle, T., Ruoff, N., Wozniak, E., Muller-Hermelink, H.K. and Vollmers, H.P. (2003) Natural IgM Antibodies and Immunosurveillance Mechanisms against Epithelial Cancer Cells in Humans. Cancer Research, 63, 7995-8005.</mixed-citation></ref><ref id="scirp.107017-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Pohle, T., Brandlein, S., Ruoff, N., Muller-Hermelink, H.K. and Vollmers, H.P. (2004) Lipoptosis: Tumor-Specific Cell Death by Antibody-Induced Intercellular Lipid Accumulation. Cancer Research, 64, 3900-3906. 
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