<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">VP</journal-id><journal-title-group><journal-title>Voice of the Publisher</journal-title></journal-title-group><issn pub-type="epub">2380-7571</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/vp.2020.64018</article-id><article-id pub-id-type="publisher-id">VP-104163</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Social Sciences&amp;Humanities</subject></subj-group></article-categories><title-group><article-title>
 
 
  A Stimulating Recollection of Chou’s Graph Theory in Enzyme Kinetics
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kuo-Chen</surname><given-names>Chou</given-names></name><xref ref-type="aff" rid="aff1"><sub>1</sub></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Gordon Life Science Institute, Boston, MA, USA</addr-line></aff><pub-date pub-type="epub"><day>16</day><month>11</month><year>2020</year></pub-date><volume>06</volume><issue>04</issue><fpage>161</fpage><lpage>163</lpage><history><date date-type="received"><day>15,</day>	<month>September</month>	<year>2020</year></date><date date-type="rev-recd"><day>14,</day>	<month>November</month>	<year>2020</year>	</date><date date-type="accepted"><day>17,</day>	<month>November</month>	<year>2020</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  In this short review paper, the significant and profound impacts of the Chou’s graph theory in enzyme kinetics have been briefly recalled with crystal clear convincingness.
 
</p></abstract><kwd-group><kwd>Graphic Theory</kwd><kwd> Enzyme Kinetics</kwd><kwd> Significant Impacts</kwd><kwd> Profound Impacts</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>Conflicts of Interest</title><p>The author declares no conflicts of interest regarding the publication of this paper.</p></sec><sec id="s2"><title>Cite this paper</title><p>Chou, K.-C. (2020). A Stimulating Recollection of Chou’s Graph Theory in Enzyme Kinetics. Voice of the Publisher, 6, 161-163. https://doi.org/10.4236/vp.2020.64018</p></sec></body><back><ref-list><title>References</title><ref id="scirp.104163-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C., Jiang, S.P., Liu, W.M. and Fee, C.H. (1979) Graph Theory of Enzyme Kinetics: 1. Steady-State Reaction System. Scientia Sinica, 22, 341-358.</mixed-citation></ref><ref id="scirp.104163-ref2"><label>2</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Zhou</surname><given-names> G.Z. </given-names></name>,<etal>et al</etal>. (<year>1979</year>)<article-title>Influence of van der Walls’ Force upon Diffusion-Controlled Reaction Rate</article-title><source> Scientia Sinica</source><volume> 17</volume>,<fpage> 845</fpage>-<lpage>858</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.104163-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. and Liu, W.M. (1981) Graphical Rules for Non-Steady State Enzyme Kinetics. Journal of Theoretical Biology, 91, 637-654.  
https://doi.org/10.1016/0022-5193(81)90215-0</mixed-citation></ref><ref id="scirp.104163-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. (1983) Advances in Graphical Methods of Enzyme Kinetics. Biophysical Chemistry, 17, 51-55. https://doi.org/10.1016/0301-4622(83)87013-6</mixed-citation></ref><ref id="scirp.104163-ref5"><label>5</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Chou</surname><given-names> K.C. </given-names></name>,<etal>et al</etal>. (<year>1989</year>)<article-title>Graphic Rules in Steady and Non-Steady Enzyme Kinetics</article-title><source> Journal of Biological Chemistry</source><volume> 264</volume>,<fpage> 12074</fpage>-<lpage>12079</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.104163-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. (1990) Review: Applications of Graph Theory to Enzyme Kinetics and Protein Folding Kinetics. Steady and Non-Steady State Systems. Biophysical Chemistry, 35, 1-24. https://doi.org/10.1016/0301-4622(90)80056-D</mixed-citation></ref><ref id="scirp.104163-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. (1993) Graphic Rule for Non-Steady-State Enzyme Kinetics and Protein Folding Kinetics. Journal of Mathematical Chemistry, 12, 97-108.  
https://doi.org/10.1007/BF01164628</mixed-citation></ref><ref id="scirp.104163-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Zhang, C.T. and Chou, K.C. (1993) Graphic Analysis of Codon Usage Strategy in 1490 Human Proteins. Journal of Protein Chemistry, 12, 329-335.  
https://doi.org/10.1007/BF01028195</mixed-citation></ref><ref id="scirp.104163-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. (2010) Graphic Rule for Drug Metabolism Systems. Current Drug Metabolism, 11, 369-378. https://doi.org/10.2174/138920010791514261</mixed-citation></ref><ref id="scirp.104163-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Wu, Z.C., Xiao, X. and Chou, K.C. (2010) 2D-MH: A Web-Server for Generating Graphic Representation of Protein Sequences Based on the Physicochemical Properties of Their Constituent Amino Acids. Journal of Theoretical Biology, 267, 29-34.  
https://doi.org/10.1016/j.jtbi.2010.08.007</mixed-citation></ref><ref id="scirp.104163-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Huang, T., Chen, L., Cai, Y.D. and Chou, K.C. (2011) Classification and Analysis of Regulatory Pathways Using Graph Property, Biochemical and Physicochemical Property, and Functional Property. PLoS ONE, 6, e25297.  
https://doi.org/10.1371/journal.pone.0025297</mixed-citation></ref><ref id="scirp.104163-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">Althaus, I.W., Chou, K.C., Franks, K.M., Diebel, M.R., Kezdy, F.J., Romero, D.L., Thomas, R.C., Aristoff, P.A., Tarpley, W.G. and Reusser, F. (1996) The Benzylthio-Pyrididine U-31,355, a Potent Inhibitor of HIV-1 Reverse Transcriptase. Biochemical Pharmacology, 51, 743-750.  
https://doi.org/10.1016/0006-2952(95)02390-9</mixed-citation></ref><ref id="scirp.104163-ref13"><label>13</label><mixed-citation publication-type="other" xlink:type="simple">Althaus, I.W., Chou, J.J., Gonzales, A.J., Diebel, M.R., Chou, K.C., Kezdy, F.J., Romero, D.L., Thomas, R.C., Aristoff, P.A., Tarpley, W.G. and Reusser, F. (1994) Kinetic Studies with the Non-Nucleoside Human Immunodeficiency Virus Type-1 Reverse Transcriptase Inhibitor U-90152e. Biochemical Pharmacology, 47, 2017-2028.  
https://doi.org/10.1016/0006-2952(94)90077-9</mixed-citation></ref><ref id="scirp.104163-ref14"><label>14</label><mixed-citation publication-type="other" xlink:type="simple">Althaus, I.W., Chou, J.J., Gonzales, A.J., Diebel, M.R., Chou, K.C., Kezdy, F.J., Romero, D.L., Aristoff, P.A., Tarpley, W.G. and Reusser, F. (1993) Kinetic Studies with the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitor U-88204E. Biochemistry, 32, 6548-6554. https://doi.org/10.1021/bi00077a008</mixed-citation></ref><ref id="scirp.104163-ref15"><label>15</label><mixed-citation publication-type="other" xlink:type="simple">Althaus, I.W., Gonzales, A.J., Chou, J.J., Diebel, M.R., Chou, K.C., Kezdy, F.J., Romero, D.L., Aristoff, P.A., Tarpley, W.G. and Reusser, F. (1993) The Quinoline U-78036 Is a Potent Inhibitor of HIV-1 Reverse Transcriptase. Journal of Biological Chemistry, 268, 14875-14880.</mixed-citation></ref><ref id="scirp.104163-ref16"><label>16</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C., Kezdy, F.J. and Reusser, F. (1994) Review: Kinetics of Processive Nucleic Acid Polymerases and Nucleases. Analytical Biochemistry, 221, 217-230.  
https://doi.org/10.1006/abio.1994.1405</mixed-citation></ref><ref id="scirp.104163-ref17"><label>17</label><mixed-citation publication-type="other" xlink:type="simple">Althaus, I.W., Chou, J.J., Gonzales, A.J., Diebel, M.R., Chou, K.C., Kezdy, F.J., Romero, D.L., Aristoff, P.A., Tarpley, W.G. and Reusser, F. (1993) Steady-State Kinetic Studies with the Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor U-87201E. Journal of Biological Chemistry, 268, 6119-6124.</mixed-citation></ref><ref id="scirp.104163-ref18"><label>18</label><mixed-citation publication-type="other" xlink:type="simple">Althaus, I.W., Chou, J.J., Gonzales, A.J., Diebel, M.R., Chou, K.C., Kezdy, F.J., Romero, D.L., Aristoff, P.A., Tarpley, W.G. and Reusser, F. (1994) Steady-State Kinetic Studies with the Polysulfonate U-9843, an HIV Reverse Transcriptase Inhibitor. Cellular and Molecular Life Science (Experientia), 50, 23-28.  
https://doi.org/10.1007/BF01992044</mixed-citation></ref><ref id="scirp.104163-ref19"><label>19</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C., Chen, N.Y. and Forsen, S. (1981) The Biological Functions of Low-Frequency Phonons: 2. Cooperative Effects. Chemica Scripta, 18, 126-132.</mixed-citation></ref><ref id="scirp.104163-ref20"><label>20</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C., Li, T.T. and Forsen, S. (1980) The Critical Spherical Shell in Enzymatic Fast Reaction Systems. Biophysical Chemistry, 12, 265-269.  
https://doi.org/10.1016/0301-4622(80)80003-2</mixed-citation></ref><ref id="scirp.104163-ref21"><label>21</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. and Forsen, S. (1980) Diffusion-Controlled Effects in Reversible Enzymatic Fast Reaction System: Critical Spherical Shell and Proximity Rate Constants. Biophysical Chemistry, 12, 255-263. https://doi.org/10.1016/0301-4622(80)80002-0</mixed-citation></ref><ref id="scirp.104163-ref22"><label>22</label><mixed-citation publication-type="other" xlink:type="simple">Li, T.T., Chou, K.C. and Forsen, S. (1980) The Flow of Substrate Molecules in Fast Enzyme-Catalyzed Reaction Systems. Chemica Scripta, 16, 192-196.</mixed-citation></ref><ref id="scirp.104163-ref23"><label>23</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. and Forsen, S. (1980) Graphical Rules for Enzyme-Catalyzed Rate Laws. Biochemical Journal, 187, 829-835. https://doi.org/10.1042/bj1870829</mixed-citation></ref><ref id="scirp.104163-ref24"><label>24</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. and Forsen, S. (1981) Graphical Rules of Steady-State Reaction Systems. Canadian Journal of Chemistry, 59, 737-755. https://doi.org/10.1139/v81-107</mixed-citation></ref><ref id="scirp.104163-ref25"><label>25</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C., Carter, R.E. and Forsen, S. (1981) A New Graphical Method for Deriving Rate Equations for Complicated Mechanisms. Chemica Scripta, 18, 82-86.</mixed-citation></ref><ref id="scirp.104163-ref26"><label>26</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C., Forsen, S. and Zhou, G.Q. (1980) Three Schematic Rules for Deriving Apparent Rate Constants. Chemica Scripta, 16, 109-113.</mixed-citation></ref><ref id="scirp.104163-ref27"><label>27</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. (2015) An Unprecedented Revolution in Medicinal Science. MOL2NET, International Conference on Multidisciplinary Sciences, Vol. 1, 1-10.</mixed-citation></ref><ref id="scirp.104163-ref28"><label>28</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. (2017) An Unprecedented Revolution in Medicinal Chemistry Driven by the Progress of Biological Science. Current Topics in Medicinal Chemistry, 17, 2337-2358. https://doi.org/10.2174/1568026617666170414145508</mixed-citation></ref></ref-list></back></article>