<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">VP</journal-id><journal-title-group><journal-title>Voice of the Publisher</journal-title></journal-title-group><issn pub-type="epub">2380-7571</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/vp.2020.63010</article-id><article-id pub-id-type="publisher-id">VP-102870</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Social Sciences&amp;Humanities</subject></subj-group></article-categories><title-group><article-title>
 
 
  The Significant and Profound Impacts of Chou’s “wenxiang” Diagram
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kuo-Chen</surname><given-names>Chou</given-names></name><xref ref-type="aff" rid="aff1"><sub>1</sub></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Gordon Life Science Institute, Boston, Massachusetts 02478, United States of America</addr-line></aff><pub-date pub-type="epub"><day>03</day><month>09</month><year>2020</year></pub-date><volume>06</volume><issue>03</issue><fpage>102</fpage><lpage>103</lpage><history><date date-type="received"><day>14,</day>	<month>August</month>	<year>2020</year></date><date date-type="rev-recd"><day>13,</day>	<month>September</month>	<year>2020</year>	</date><date date-type="accepted"><day>16,</day>	<month>September</month>	<year>2020</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  In this short review paper, the significant and profound impacts of the Chou’s “wenxiang diagram” have been briefly presented with crystal clear convincingness.
 
</p></abstract><kwd-group><kwd>Wenxiang Diagram</kwd><kwd> Significant Impacts</kwd><kwd> Profound Impacts</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>Conflicts of Interest</title><p>The author declares no conflicts of interest regarding the publication of this paper.</p></sec><sec id="s2"><title>Cite this paper</title><p>Chou, K.-C. (2020). The Significant and Profound Impacts of Chou’s “wenxiang” Diagram. Voice of the Publisher, 6, 102-103. https://doi.org/10.4236/vp.2020.63010</p></sec></body><back><ref-list><title>References</title><ref id="scirp.102870-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C., Liu, W., Maggiora, G.M. and Zhang, C.T. (1998) Prediction and Classification of Domain Structural Classes. Proteins: Structure, Function, and Bioinformatics, 31, 97-103.  
https://doi.org/10.1002/(SICI)1097-0134(19980401)31:1&lt;97::AID-PROT8&gt;3.0.CO;2-E</mixed-citation></ref><ref id="scirp.102870-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Chou, K.C. and Maggiora, G.M. (1998) Domain Structural Class Prediction. Protein Engineering, 11, 523-538. https://doi.org/10.1093/protein/11.7.523</mixed-citation></ref><ref id="scirp.102870-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Zhou, G.P. (2011) The Disposition of the LZCC Protein Residues in Wenxiang Diagram Provides New Insights into the Protein-Protein Interaction Mechanism. Journal of Theoretical Biology, 284, 142-148.  
https://doi.org/10.1016/j.jtbi.2011.06.006</mixed-citation></ref><ref id="scirp.102870-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Zhou, G.P., Chen, D., Liao, S. and Huang, R.B. (2016) Recent Progresses in Studying Helix-Helix Interactions in Proteins by Incorporating the Wenxiang Diagram into the NMR Spectroscopy. Current Topics in Medicinal Chemistry, 16, 581-590.  
https://doi.org/10.2174/1568026615666150819104617</mixed-citation></ref><ref id="scirp.102870-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Cai, Y.D. and Zhou, G.P. (2000) Prediction of Protein Structural Classes by Neural Network. Biochimie, 82, 783-785. https://doi.org/10.1016/S0300-9084(00)01161-5</mixed-citation></ref><ref id="scirp.102870-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Zhou, G.P. and Assa-Munt, N. (2001) Some Insights into Protein Structural Class Prediction. Proteins: Structure, Function, and Bioinformatics, 44, 57-59.  
https://doi.org/10.1002/prot.1071</mixed-citation></ref><ref id="scirp.102870-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Cai, Y.D., Zhou, G.P. and Chou, K.C. (2003) Support Vector Machines for Predicting Membrane Protein Types by Using Functional Domain Composition. Biophysical Journal, 84, 3257-3263. https://doi.org/10.1016/S0006-3495(03)70050-2</mixed-citation></ref><ref id="scirp.102870-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Zhou, G.P. and Doctor, K. (2003) Subcellular Location Prediction of Apoptosis Proteins. Proteins: Structure, Function, and Bioinformatics, 50, 44-48.  
https://doi.org/10.1002/prot.10251</mixed-citation></ref><ref id="scirp.102870-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Cai, Y.D., Zhou, G.P., Jen, C.H., Lin, S.L. and Chou, K.C. (2004) Identify Catalytic Triads of Serine Hydrolases by Support Vector Machines. Journal of Theoretical Biology, 228, 551-557. https://doi.org/10.1016/j.jtbi.2004.02.019</mixed-citation></ref><ref id="scirp.102870-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Zhou, G.P. and Cai, Y.D. (2006) Predicting Protease Types by Hybridizing Gene Ontology and Pseudo Amino Acid Composition. Proteins: Structure, Function, and Bioinformatics, 63, 681-684. https://doi.org/10.1002/prot.20898</mixed-citation></ref><ref id="scirp.102870-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Zhou, G.P. and Huang, R.B. (2013) The pH-Triggered Conversion of the PrP(c) to PrP(sc.). Current Topics in Medicinal Chemistry, 13, 1152-1163.  
https://doi.org/10.2174/15680266113139990003</mixed-citation></ref><ref id="scirp.102870-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">Lu, B., Liu, X.H., Lia, S.M., Lu, L.Z., Chen, D., Troy II, F.A., Huang, R.B. and Zhou, G.P. (2019) A Possible Modulation Mechanism of Intramolecular and Intermolecular Interactions for NCAM Polysialylation and Cell Migration. Current Topics in Mecinal Chemistry, 19.  
https://doi.org/10.2174/1568026619666191018094805    
http://www.eurekaselect.com/175822/article</mixed-citation></ref></ref-list></back></article>