<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">WJNS</journal-id><journal-title-group><journal-title>World Journal of Neuroscience</journal-title></journal-title-group><issn pub-type="epub">2162-2000</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/wjns.2020.102013</article-id><article-id pub-id-type="publisher-id">WJNS-100265</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biomedical&amp;Life Sciences</subject></subj-group></article-categories><title-group><article-title>
 
 
  Immunotherapy for the Post-Infectious Sequela of SARS-CoV-2 Infection
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>David</surname><given-names>S. Younger</given-names></name><xref ref-type="aff" rid="aff1"><sub>1</sub></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>School of Medicine, City University of New York, New York, NY, USA</addr-line></aff><pub-date pub-type="epub"><day>09</day><month>04</month><year>2020</year></pub-date><volume>10</volume><issue>02</issue><fpage>117</fpage><lpage>120</lpage><history><date date-type="received"><day>7,</day>	<month>May</month>	<year>2020</year></date><date date-type="rev-recd"><day>15,</day>	<month>May</month>	<year>2020</year>	</date><date date-type="accepted"><day>18,</day>	<month>May</month>	<year>2020</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  The SARS-CoV-2 2019 pandemic is creating challenges to the management of post-infectious autoimmunity in childhood and adult Covid-19 cases due to its high case fatality. Nearly all of the agents envisioned to treat Covid-19 illness, including the newly recognized pediatric multi-system inflammatory syndrome, impact post-infectious mechanisms in keeping with the multiplier effect of infection, immunity and inflammation, known as I-Cubed (I
  <sup>3</sup>
  ).
 
</p></abstract><kwd-group><kwd>SARS-CoV-2</kwd><kwd> Covid-19</kwd><kwd> Intravenous Immune Globulin</kwd><kwd> IVIg</kwd><kwd> Pediatric  Multi-System Inflammatory Syndrome</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>Conflicts of Interest</title><p>The author declares no conflicts of interest regarding the publication of this paper.</p></sec><sec id="s2"><title>Cite this paper</title><p>Younger, D.S. (2020) Immunotherapy for the Post-Infectious Sequela of SARS-CoV-2 Infection. World Journal of Neuroscience, 10, 117-120. https://doi.org/10.4236/wjns.2020.102013</p></sec></body><back><ref-list><title>References</title><ref id="scirp.100265-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Guo, X.J. and Thomas, P.G. (2017) New Fronts Emerge in the Influenza Cytokine Storm. Seminars in Immunopathology, 39, 541-550. https://doi.org/10.1007/s00281-017-0636-y</mixed-citation></ref><ref id="scirp.100265-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Guan, W.J., Ni, Z.Y., Hu, Y., et al. (2020) Clinical Characteristics of Coronavirus Disease 2019 in China. The New England Journal of Medicine, 382, 1708-1720. https://doi.org/10.1056/NEJMoa2002032</mixed-citation></ref><ref id="scirp.100265-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Younger, D.S. (2016) I-Cubed (Infection, Immunity, and Inflammation) and the Human Microbiome. Neurologic Clinics, 34, 863-874. https://doi.org/10.1016/j.ncl.2016.05.006</mixed-citation></ref><ref id="scirp.100265-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Biot, C., Daher, W., Chavain, N., et al. (2006) Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities. Journal of Medicinal Chemistry, 49, 2845-2849. https://doi.org/10.1021/jm0601856</mixed-citation></ref><ref id="scirp.100265-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Gautret, P., Lagier, J.C., Parola, P., et al. (2020) Hydroxychloroquine and Azithromycin as a Treatment of COVID-19: Results of an Open-Label Non-Randomized Clinical Trial. International Journal of Antimicrobial Agents, 2020, Article ID: 105949.</mixed-citation></ref><ref id="scirp.100265-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Geleris, J., Sun, Y., Platt, J., et al. (2020) Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa2012410</mixed-citation></ref><ref id="scirp.100265-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Grein, J., Ohmagari, N., Shin, D., et al. (2020) Compassionate Use of Remdesivir for Patients with Severe Covid-19. The New England Journal of Medicine.</mixed-citation></ref><ref id="scirp.100265-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Shen, C., Wang, Z., Zhao, F., et al. (2020) Treatment of 5 Critically Ill Patients with COVID-19 with Convalescent Plasma. JAMA, 323, 1582-1589. https://doi.org/10.1001/jama.2020.4783</mixed-citation></ref><ref id="scirp.100265-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Cao, W., Liu, X., Bai, T., et al. (2020) High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients with Coronavirus Disease 2019. Open Forum Infectious Diseases, 7, ofaa102. https://doi.org/10.1093/ofid/ofaa102</mixed-citation></ref><ref id="scirp.100265-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Harahsheh, A.S., Dahdah, N., Newburger, J.W., et al. (2020) Missed or Delayed Diagnosis of Kawasaki Disease during the 2019 Novel Coronavirus Disease (COVID-19) Pandemic. The Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2020.04.052</mixed-citation></ref><ref id="scirp.100265-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Younger, D.S. (2020) Post-Infectious Sequela of SARS-COV-2 Infection in Adults and Children: An Overview of Available Agents and Clinical Responsiveness. Arch Neurology and Neurological Disorder, 3, e102.</mixed-citation></ref></ref-list></back></article>