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Perez-Martinez, P., Delgado-Lista, J., Garcia-Rios, A., Tierney, A.C., Gulseth, H.L., Williams, C.M., Karlstrom, B., Kiec-Wilk, B., Blaak, E.E., Helal, O., Saris, W.H., Defoort, C., Drevon, C.A., Lovegrove, J.A., Dembinska-Kiec, A., Riserus, U., Roche, H.M. and Lopez-Miranda, J (2012) Insulin receptor substrate-2 gene variants in subjects with metabolic syndrome: Association with plasma monounsaturated and n-3 polyunsaturated fatty acid levels and insulin resistance. Molecular Nutrition & Food Research, 56, 309-315. http://dx.doi.org/10.1002/mnfr.201100504

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• TITLE: Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components

  AUTHORS: Fulden Sarac, Afig Berdeli, Sefa Sarac, Sumru Savas, Merve Atan, Fehmi Akcicek

  KEYWORDS: Metabolic Syndrome; Insulin Receptor Substrat-1 Gene; Insulin Receptor Substrat-2 Gene

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.3 No.4, November 12, 2013

  ABSTRACT: Aim: Metabolic syndrome (MetS) is a major risk factor for both diabetes mellitus and cardiovascular disease (CVD). The aims of the study were 1) to investigate the insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) gene polymorphisms in patients with MetS and 2) to examine the relationships between gene polymorphisms and components of MetS. Patients & Methods: The study population included 100 patients with MetS and 30 patients without MetS as control group. Metabolic syndrome (MS) was defined as in ATP III. Entire coding exons of IRS-1 and IRS-2 genes were amplified by polymerase chain reaction (PCR). Insulin resistance (IR) was estimated using the homeostasis model assessment (HOMA). Results: In patients with MetS, 34 (34%), had G972R (rs1801278) gene polymorphism and 66 (66%) had no nucleotide substitutions at the IRS-1 gene (p circumference, blood pressure, triglyceride, HDL-Cholesterol, LDL-Cholesterol and HOMA-IR levels. Conclusion: Insulin receptor substrate-1 and 2 gene polymorphisms were associated with metabolic syndrome but not its components.