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Clausen, J.O., Hansen, T., Bjorbaek, C., Echwald, S.M., Urhammer, S.A., Rasmussen, S., Andersen, C.B., Hansen, L., Almind, K., Winther, K., Haraldsdottir, J., Borch-Johnsen, K. and Pedersen, O. (1995) Insulin resistance: Interactions between obesity and a common variant of insulin receptor substrate-1. Lancet, 346, 397-402. http://dx.doi.org/10.1016/S0140-6736(95)92779-4

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• TITLE: Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components

  AUTHORS: Fulden Sarac, Afig Berdeli, Sefa Sarac, Sumru Savas, Merve Atan, Fehmi Akcicek

  KEYWORDS: Metabolic Syndrome; Insulin Receptor Substrat-1 Gene; Insulin Receptor Substrat-2 Gene

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.3 No.4, November 12, 2013

  ABSTRACT: Aim: Metabolic syndrome (MetS) is a major risk factor for both diabetes mellitus and cardiovascular disease (CVD). The aims of the study were 1) to investigate the insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) gene polymorphisms in patients with MetS and 2) to examine the relationships between gene polymorphisms and components of MetS. Patients & Methods: The study population included 100 patients with MetS and 30 patients without MetS as control group. Metabolic syndrome (MS) was defined as in ATP III. Entire coding exons of IRS-1 and IRS-2 genes were amplified by polymerase chain reaction (PCR). Insulin resistance (IR) was estimated using the homeostasis model assessment (HOMA). Results: In patients with MetS, 34 (34%), had G972R (rs1801278) gene polymorphism and 66 (66%) had no nucleotide substitutions at the IRS-1 gene (p circumference, blood pressure, triglyceride, HDL-Cholesterol, LDL-Cholesterol and HOMA-IR levels. Conclusion: Insulin receptor substrate-1 and 2 gene polymorphisms were associated with metabolic syndrome but not its components.