TITLE:
Some pharmacological studies on the methanolic extract of Inula graveolense L.
AUTHORS:
Adnan J. M. Al-Fartosy
KEYWORDS:
Pharmacological Activities; Antidiarrhae; Antipyretic; Anti-Inflammatory; Antinociceptive; Anti-Denaturation; Platelet Aggregation; Inula graveolens L.
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.6 No.11,
November
11,
2013
ABSTRACT: Inula graveolens L. is widely used in Iraq for the treatment of rheumatic fever, infant convulsions, toothache, blood sugar, and also to dissolve internal blood clots, and to aid digestion. However, the efficacy and mechanisms of action of the plant remain unclear. Therefore, the objective of the present study was to investigate the pharmacological effects of the methanolic extract (MEIG) of this plant belonging to compositae family. Anti-diarrheal and antipyretic activities of the extract were examined in rats. Anti-inflammatory and antinociceptive were studied in mice. At the doses of 200 (P in vitro protein anti-denaturation using Bovine serum albumin and anti-platelet aggregation of human blood activity. It was observed that the extract showed greater percentage of inhibition of BSA (P potential platelet aggregation inhibitory activity in adose-dependent manner. The maximum inhibition was observed at the dose 400 μg/ml (P