TITLE:
Impact of Postoperative Radiotherapy and Chemotherapy on Survival for Patients with Node Positive Oral Cancer
AUTHORS:
Mohamed Mahmoud, Tarek Shouman, Hesham Elhosseny, Mona Aboelenin, Mohamed Amin
KEYWORDS:
Concurrent Radiotherapy and Chemotherapy; Intensity Modulated Radiotherapy; Image Guided Radiotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.11A,
November
11,
2013
ABSTRACT: Purpose: The aim of the present study is
to compare between the use of post-operative concurrent chemotherapy and
radiotherapy alone on survival for patients with high risk oral cavity tumors
at the National cancer Institute of Egypt, undergoing surgery and receiving
adjuvant treatment. Patients and Methods: This is a retrospective study, which was carried out at the National Cancer
Institute (Cairo University) on patients with node positive oral cavity cancer
diagnosed between the year 2000 and 2008. The study included 60 patients (45
males and 15 females) with median age 57 years old. The patients underwent
surgery, followed by postoperative radiotherapy 60 Gy/6 weeks versus
postoperative radiotherapy 60 Gy/6 weeks with concurrent cisplatin 100 mg/m2 at day 1, day 22 and day 43. Results: Regarding use of concurrent chemotherapy, there was a significant difference in
overall survival rate and locoregional control favoring patients who received
concurrent chemotherapy and radiotherapy, 3 years and 5 years overall survival
rates respectively were 53.8% and 40.4% compared to 37.5% and 26.3% for
patients who didn’t receive any chemotherapy with (p 0.038)
for 5 years. Regarding age, there was a significant difference in overall
survival rate favoring patients ≤57 years in both arm groups, 3 years and 5
years overall survival rates respectively were 51.6% and 38.9% compared to
28.3% and 18.9% for patients >57 years with (p 0.028) for 5
years. Conclusion: We recommend for
oral cavity tumor patients at the NCI of Egypt who have positive neck nodes to
be treated with concurrent chemo-radiotherapy rather than radiotherapy alone especially
by using the new techniques as intensity modulated radiotherapy (IMRT) and
image guided radiotherapy (IGRT).