Article citationsMore>>

J. Yang, X. Fu, Q. Jia, J. Shen, J. B. Biggins, J. Jiang, J. Zhao, J. J. Schmidt, P. G. Wang and J. S. Thorson, “Studies on the Substrate Specificity of Escherichia coli Galactokinase,” Organic Letters, Vol. 5, No. 13, 2003, pp. 2223-2226. http://dx.doi.org/10.1021/ol034642d

has been cited by the following article:

• TITLE: Improvement on the Synthesis of Primary Amino Sugar Derivatives via N-Benzyl Intermediates

  AUTHORS: Massimo Corsi, Marco Bonanni, Giorgio Catelani, Felicia D’Andrea, Tiziana Gragnani, Roberto Bianchini

  KEYWORDS: Amino Sugars; Nucleophilic Substitution; Benzylamine; Primary Tosylates

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.3A, November 6, 2013

  ABSTRACT: Primary tosylates 1a-d were converted to the corresponding amino species 3a-d. Benzylamine was proved effective for the substitution of tosylates, using acetonitrile (MeCN) as the solvent of choice and citric acid to remove excess of the reagent from crude products 2a-d. Debenzylation was carried out at circa (ca.) atmospheric pressure of hydrogen gas in the presence of acetic acid (AcOH). The method was also demonstrated in a demo batch experiment for the synthesis of compound 3a on a 50 g scale of 1a.