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A. H. Ingall, J. Dixon, A. Bailey, M. E. Coombs, D. Cox, J. I. McInally, S. F. Hunt, N. D. Kindon, B. J. Teobald, P. A. Willis, R. G. Humphries, P. Leff, J. A. Clegg, J. A. Smith and W. Tomlinson, “Antagonists of the Platelet P2T Receptor: A Novel Approach to Anti-Thrombotic Therapy,” Journal of Medicinal Chemistry, Vol. 42, No. 2, 1999, pp. 213-220.
http://dx.doi.org/10.1021/jm981072s

has been cited by the following article:

• TITLE: Novel Synthesis Approach and Antiplatelet Activity Evaluation of 6-Arylmethyleneamino-2-Alkylsulfonylpyrimidin-4(3H)-one Derivatives and Its Nucleosides

  AUTHORS: Abdulrahman G. Alshammari, Abdel-Rhman B. A. El-Gazzar

  KEYWORDS: Natural Asset; Financial Value; Neural Network

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.3A, November 6, 2013

  ABSTRACT: A new and efficient procedure has been designed for the preparation of 6-arylmethylene-amino-2-alkyl sulfonyl-pyrimidine. The first alkylthio group was introduced into the pyrimidine ring by S-alkylation. The introduction of the second one was successfully achieved using the phosphorous oxychloride method to afford 4-chloro-2-alkylthio-pyrimidines. Subsequent nucleophilic displacement by the corresponding alkylamines followed by glycoside bromide addition conveniently gave a series of the target compounds. Thus, the two same or different alkylamino groups were easily introduced into the pyrimidine ring through the two different approaches. The human anti-platelet aggregation activity of the newly synthesized compounds was also described.