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B. Xu, A. Stephens, G. Kirschenheuter, A. F. Greslin, X. Cheng, J. Sennelo, M. Cattaneo, M. L. Zighetti, A. Chen, S. A. Kim, H. S. Kim, N. Bischofberger, G. Cook and K. A. Jacobson, “Acyclic Analogues of Adenosine Bisphosphates as P2Y Receptor Antagonists: Phosphate Substitution Leads to Multiple Pathways of Inhibition of Platelet Aggregation,” Journal of Medicinal Chemistry, Vol. 45, No. 26, 2002, pp. 5694-5709.
http://dx.doi.org/10.1021/jm020173u

has been cited by the following article:

• TITLE: Novel Synthesis Approach and Antiplatelet Activity Evaluation of 6-Arylmethyleneamino-2-Alkylsulfonylpyrimidin-4(3H)-one Derivatives and Its Nucleosides

  AUTHORS: Abdulrahman G. Alshammari, Abdel-Rhman B. A. El-Gazzar

  KEYWORDS: Natural Asset; Financial Value; Neural Network

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.3A, November 6, 2013

  ABSTRACT: A new and efficient procedure has been designed for the preparation of 6-arylmethylene-amino-2-alkyl sulfonyl-pyrimidine. The first alkylthio group was introduced into the pyrimidine ring by S-alkylation. The introduction of the second one was successfully achieved using the phosphorous oxychloride method to afford 4-chloro-2-alkylthio-pyrimidines. Subsequent nucleophilic displacement by the corresponding alkylamines followed by glycoside bromide addition conveniently gave a series of the target compounds. Thus, the two same or different alkylamino groups were easily introduced into the pyrimidine ring through the two different approaches. The human anti-platelet aggregation activity of the newly synthesized compounds was also described.