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S. W. Kortum, R. M. Lachance, B. A. Schweitzer, G. Yalamanchili, H. Rahman, M. D. Ennis, R. M. Huff and R. E. Tenbrink, “Thienopyrimidine-Based P2Y12 Platelet Aggregation Inhibitors,” Bioorganic & Medicinal Chemistry Letters, Vol. 19, No. 20, 2009, pp. 5919-5923.
http://dx.doi.org/10.1016/j.bmcl.2009.08.059

has been cited by the following article:

• TITLE: Novel Synthesis Approach and Antiplatelet Activity Evaluation of 6-Arylmethyleneamino-2-Alkylsulfonylpyrimidin-4(3H)-one Derivatives and Its Nucleosides

  AUTHORS: Abdulrahman G. Alshammari, Abdel-Rhman B. A. El-Gazzar

  KEYWORDS: Natural Asset; Financial Value; Neural Network

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.3A, November 6, 2013

  ABSTRACT: A new and efficient procedure has been designed for the preparation of 6-arylmethylene-amino-2-alkyl sulfonyl-pyrimidine. The first alkylthio group was introduced into the pyrimidine ring by S-alkylation. The introduction of the second one was successfully achieved using the phosphorous oxychloride method to afford 4-chloro-2-alkylthio-pyrimidines. Subsequent nucleophilic displacement by the corresponding alkylamines followed by glycoside bromide addition conveniently gave a series of the target compounds. Thus, the two same or different alkylamino groups were easily introduced into the pyrimidine ring through the two different approaches. The human anti-platelet aggregation activity of the newly synthesized compounds was also described.