Article citationsMore>>

D. R. Hepburn and H. R. Hudson, “Factors in the Formation of Isomerically and Optically Pure Alkyl Halides. Part XI. Vilsmeier Reagents for the Replacement of a Hydroxy-Group by Chlorine or Bromine,” Journal of the Chemical Society, Perkin Transactions 1, No. 7, 1976, pp. 754-757. http://dx.doi.org/10.1039/P19760000754

has been cited by the following article:

• TITLE: Novel Synthetic Method for the Vilsmeier-Haack Reagent and Green Routes to Acid Chlorides, Alkyl Formates, and Alkyl Chlorides

  AUTHORS: Yoshikazu Kimura, Daisuke Matsuura

  KEYWORDS: Phthaloyl Dichloride; Vilsmeier-Haack Reagent; Acid Chlorides; Alkyl Formates; Alkyl Chlorides

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.3A, November 5, 2013

  ABSTRACT: An environmentally benign and practical preparation method for the Vilsmeier-Haack reagent (VH) has been developed by using phthaloyl dichloride with DMF in toluene or 2-chlorotoluene. Phthalic anhydride as the byproduct was recovered in high yield by simple filtration. Some aromatic acids have been transformed into the corresponding acid chlorides in good yields by employing the isolated VH. Treatment of primary or secondary alcohols with VH gave alkyl formates or alkyl chlorides by depending on the reaction conditions.