TITLE:
Resolution of Alcohol Racemate by Oil
AUTHORS:
Adi Wolfson, Nadia Komyagina, Christina Dlugy, Janine Blumenfeld
KEYWORDS:
Oil, Kinetic Resolution, Lipase, Separation
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.1 No.1,
March
14,
2011
ABSTRACT: Vegetable oil was successfully used as solvent and acyl donor in the kinetic resolution of several secondary alcohol racemates yielding high enantioselectivities. Using vegetable oil as solvent and acyl donor allowed easy separation of the pure alcohol enantiomer by extraction with methanol, by distillation under reduced pressure, or by column chromatography.