TITLE:
Biaxial Constitutive Model of Active Coronary Media Based on Microstructural Information
AUTHORS:
Huan Chen, Yunlong Huo, Ghassan S. Kassab
KEYWORDS:
Biaxial Constitutive Model; Cell Deformation; Morphology; Vascular Smooth Muscle Cell
JOURNAL NAME:
Engineering,
Vol.5 No.10B,
November
1,
2013
ABSTRACT: Detailed morphological data of vascular smooth muscle
cells (VSMC) of coronary arteries were limited. The present study was to
quantify dimensions and orientation of swine coronary VSMC and to develop a
micro-structural constitutive model of active media. It was found that
geometrical parameters of VSMC (length, width, spatial aspect ratio, and
orientation) follow normal distributions, and VSMCs orientate towards the
circumferential direction of vessels with oblique and symmetrical angles. A
micro-structural model of media layer was developed toaccurately
predict biaxial active responses of coronary arterial media, based on
experimental measurements. The present morphological data base and
micro-structural model lead to a better understanding of biomechanics of
muscular vessels.