TITLE:
In Silico Molecular Interaction Studies of Suberoylanilide Hydroxamic Acid and Its Modified Compounds with Histones Deacetylase Class II Homo sapiens as Curative Measure towards Cervical Cancer
AUTHORS:
Usman Sumo Friend Tambunan, Arli Aditya Parikesit, Tirtana Prasetia, Djati Kerami
KEYWORDS:
Cervical Cancer; HPV; HDAC; SAHA; LigX; Dynamics Simulations
JOURNAL NAME:
Engineering,
Vol.5 No.10B,
October
31,
2013
ABSTRACT: The threat of cervical cancer is a serious problem for
the women’s health. It is already known that the cause of cervical cancer is
definitely HPV (Human Papilloma Virus).
The drug development is the most reasonable approach for coping with HPV
infection. The development of HDACi (Histone Deacetylase inhibitor) is seen as
a feasible method for curing the threat of cervical cancer. Rational drug
design is our utilized pipeline for drug development. The LigX MOE-based method
has been developed to investigate the molecular interaction of HDAC class IIHomo sapienswith the designed lead
compound. The method has found that ligands 1c, 2a,
and 2c are indeed feasible to
be formulated as drug candidates.