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K. A. Smith, C. G. Fairburn and P. J. Cowen, “Relapse of Depression after Rapid Depletion of Tryptophan,” Lancet, Vol. 349, No. 9056, 1997, pp. 915-919. http://dx.doi.org/10.1016/S0140-6736(96)07044-4

has been cited by the following article:

• TITLE: Theoretical Study of 5-HTP. Potential New Drug Resulting from the Complexation of 5-HTP with ATP

  AUTHORS: Josette Weinberg, Dan A. Lerner

  KEYWORDS: ATP; 5-HTP; Density Functional Theory (DFT); NBO

  JOURNAL NAME: Computational Chemistry, Vol.1 No.1, October 29, 2013

  ABSTRACT: 5-HTP (5-Hydroxytryptophan), is the precursor of the neurotransmitter serotonin. Molecular parameters (interatomic distances and angles, total atomic charge, dipole moments) of 5-HTP (5-Hydroxytryptophan) and ATP (Adenosine triphosphate), and of their possible complex, including its heat of formation, have been computed in an ab initio study involving DFT calculations. The 6-31G* basis set and the B3LYP functional were employed. The aim of this study is to emphasize by DFT calculation the possible existence of a complex between ATP and 5-HTP that may have the properties of a new drug. A Natural Bond Orbital analysis description offers supplementary details for the structure of the molecular units and their interaction.