TITLE:
Ketoprofen/ethyl Cellulose Nanofibers Fabricated Using an Epoxy-coated Spinneret
AUTHORS:
Xiao-Yan Li, Deng-Guang Yu, Cai-Tao Fu, Rui Wang, Xia Wang
KEYWORDS:
Electrospinning; Nanofibers; Sustained Drug Release; Ethyl Cellulose
JOURNAL NAME:
Modeling and Numerical Simulation of Material Science,
Vol.3 No.4B,
October
28,
2013
ABSTRACT: The present study investigates the preparation of
sustained release drug-loaded nanofibers using a novel epoxy-coated spinneret.
With ethyl cellulose (EC) and ketoprofen (KET) as the filament-forming matrix
and the active pharmaceutical ingredient, Drug-loaded composite nanofibers are generated
smoothly and continuously with few user interventions. Field-emission scanning
electron microscopic observations demonstrated that the composite nanofibers
prepared using the epoxy-coated spinneret have better quality than those from a
traditional stainless steel spinneret in terms of diameter and its distribution.
Both of the composite nanofibers are in essential a molecular solid
dispersion of EC and KET based on the hydrogen bonding between them, as
verified by XRD and ATR-FTIR results. In
vitro dissolution tests show that the nanofibers resulted from the new
spinneret provide a finer sustained KET release profile than their
counter-parts. Epoxy-coated spinneret is a useful tool to facilitate the
electrospinning process through the prevention of clogging for generating high
quality nanofibers.