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D. G. Yu, C. Branford-White, N. P. Chatterton, K. White, L. M. Zhu, X. X. Shen and W. Nie, “Electrospinning of Concentrated Polymer Solutions,” Macromolecules, Vol. 43, No. 24, 2010, pp. 10743-10746. doi: 10.1021/ma1024363

has been cited by the following article:

• TITLE: Ketoprofen/ethyl Cellulose Nanofibers Fabricated Using an Epoxy-coated Spinneret

  AUTHORS: Xiao-Yan Li, Deng-Guang Yu, Cai-Tao Fu, Rui Wang, Xia Wang

  KEYWORDS: Electrospinning; Nanofibers; Sustained Drug Release; Ethyl Cellulose

  JOURNAL NAME: Modeling and Numerical Simulation of Material Science, Vol.3 No.4B, October 28, 2013

  ABSTRACT: The present study investigates the preparation of sustained release drug-loaded nanofibers using a novel epoxy-coated spinneret. With ethyl cellulose (EC) and ketoprofen (KET) as the filament-forming matrix and the active pharmaceutical ingredient, Drug-loaded composite nanofibers are generated smoothly and continuously with few user interventions. Field-emission scanning electron microscopic observations demonstrated that the composite nanofibers prepared using the epoxy-coated spinneret have better quality than those from a traditional stainless steel spinneret in terms of diameter and its distribution. Both of the composite nanofibers are in essential a molecular solid dispersion of EC and KET based on the hydrogen bonding between them, as verified by XRD and ATR-FTIR results. In vitro dissolution tests show that the nanofibers resulted from the new spinneret provide a finer sustained KET release profile than their counter-parts. Epoxy-coated spinneret is a useful tool to facilitate the electrospinning process through the prevention of clogging for generating high quality nanofibers.