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D.G. Yu, X. Wang, X. Y. Li, W. Chian, Y. Li and Y. Z. Liao, “Electrospun Biphasic Drug Release Polyvinylpyrrolidone/ ethyl Cellulose Core/sheath Nanofibers,” Acta Biomaterialia, Vol. 9, No. 3, 2013, pp. 5665-5672. doi: 10.1016/j.actbio.2012.10.021

has been cited by the following article:

• TITLE: Ketoprofen/ethyl Cellulose Nanofibers Fabricated Using an Epoxy-coated Spinneret

  AUTHORS: Xiao-Yan Li, Deng-Guang Yu, Cai-Tao Fu, Rui Wang, Xia Wang

  KEYWORDS: Electrospinning; Nanofibers; Sustained Drug Release; Ethyl Cellulose

  JOURNAL NAME: Modeling and Numerical Simulation of Material Science, Vol.3 No.4B, October 28, 2013

  ABSTRACT: The present study investigates the preparation of sustained release drug-loaded nanofibers using a novel epoxy-coated spinneret. With ethyl cellulose (EC) and ketoprofen (KET) as the filament-forming matrix and the active pharmaceutical ingredient, Drug-loaded composite nanofibers are generated smoothly and continuously with few user interventions. Field-emission scanning electron microscopic observations demonstrated that the composite nanofibers prepared using the epoxy-coated spinneret have better quality than those from a traditional stainless steel spinneret in terms of diameter and its distribution. Both of the composite nanofibers are in essential a molecular solid dispersion of EC and KET based on the hydrogen bonding between them, as verified by XRD and ATR-FTIR results. In vitro dissolution tests show that the nanofibers resulted from the new spinneret provide a finer sustained KET release profile than their counter-parts. Epoxy-coated spinneret is a useful tool to facilitate the electrospinning process through the prevention of clogging for generating high quality nanofibers.