TITLE:
Relationships between a Thiol-Disulfide System and Liposoluble Antioxidants with Cytogenetic Indices in Humans Exposed to Low Doses Radiation
AUTHORS:
G. F. Ivanenko, E. B. Burlakova
KEYWORDS:
Antioxidant; Radiation; Plasma; Human Population
JOURNAL NAME:
Engineering,
Vol.5 No.10B,
October
25,
2013
ABSTRACT: This work presents the results of biochemical
examination of people exposed to irradiation as a result of the Chernobyl
catastrophe. In remote period ( in 4, 5, 6 and 7 years) after Chernobyl
accident we studied the state of the redox system of glutathione(GSH, GSSG) and
the response of the system of essential lipid antioxidants (vitamin E, A) in
blood plasma of people of various ages. An analysis of correlations between
cytogenetic indices in lymphocytes and levels of reduced glutathione
and liposoluble antioxidants in the plasma of peripheral blood in children born
after the Chernobyl accident and liquidators is presented. The cumulative doses
for the examined group of children received by their mothers
from 0.8 to 70 cSv and liquidators received, on average, the highest
irradiation doses from 0.1 to 150 cSv. A complex relationship
between lipo-and water-soluble antioxidants level in plasma in human population
(children living in radionuclide-contaminated regions and the Chernobyl
liquidators) exposed to chronic low-level radiation after the Chernobyl
accident was demonstrated. The obtained experimental data indicate different
responses of the human population water-and fat-soluble antioxidants
system to low (from 0.1 to 20 cSv) and high (from 20 to 150 cSv) doses of
ionizing radiation.