TITLE:
Mathematical Modeling of Hemoglobin Release under Hypotonic Conditions
AUTHORS:
Ivana Pajic-Lijakovic, Branko Bugarski, Milenko Plavsic
KEYWORDS:
Hemoglobin Transport; Hemolytic Hole; Thermodynamics; Cellular Biology and Engineering; Mathematical Modeling
JOURNAL NAME:
Engineering,
Vol.4 No.10B,
October
21,
2013
ABSTRACT: Mathematical model is
developed to estimate hemoglobin release under hypotonic conditions at
microscopic level. The phenomenon of hemoglobin (Hb) release depends on: 1) the
dynamics of repeated opening of hemolytic holes and 2) the radial fluctuations
of lipid membrane. Both processes are sensitive to the rate of ionic strength
decrease within the surrounding medium. Influence of the rate of ionic strength
decrease on hemoglobin release is quantified by the model parameters: 1) the
specific decrease of erythrocyte radius and 2) the specific decrease of hole
radius during single opening time period of hemolytic hole. The prediction of
released amount of Hb influenced by the conductive mechanism is equal to 2.9 %.
The prediction of total released amount of Hb influenced by the conductive and
convective mechanisms is approximately equal to 4 % of the initial amount of Hb
within erythrocyte.