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Wan L,Hyo-Im C,Mi-Jin K, et a.l Depletion ofmitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability.Exp.Mo.lMed, 2008, 40(1): 109-117.

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• TITLE: Conditional Replication Adenovirus Sensitizes A549 Cancer Cell to Cisplatin

  AUTHORS: Yanan Liu, Yinghui Huang

  KEYWORDS: Cisplatin; Adenovirus; Lung Cancer

  JOURNAL NAME: Engineering, Vol.4 No.10B, October 21, 2013

  ABSTRACT: Objective: The aim of the study was to improve the therapeutic effect for lung cancer using a synergetic strategy of adenovirus-based gene therapy combined with chemotherapy. Methods: A conditional replication adenovirus(CRAd) was employed to treat the A549 lung cancer cells and cisplatin-resisted A549(A549-DDP) cells. In vitro MTS / PMS assay were used to evaluate the cell viability. PCR were used to detect expression of Coxsackie receptor (CAR) and Multidrug resistance(MDR) gene. The in vivo anti-tumor effect of CRAd and cisplatin was evaluated using a subcutaneous mouse model. Results: The CRAd sensitizes A549 cancer cells to cisplatin. The mechanism of enhanced cell growth inhibition is associated with the increased CAR and MDR expression. Conclusion: Our approach is better than the conventional gene therapy and chemotherapy strategy.