TITLE:
Renewing Oncological Hyperthermia—Oncothermia
AUTHORS:
Oliver Szasz
KEYWORDS:
Hyperthermia; Oncothermia; Oncology; Nano-Heating; Focusing; Selection; Apoptosis; Immune-Support
JOURNAL NAME:
Open Journal of Biophysics,
Vol.3 No.4,
October
18,
2013
ABSTRACT: Hyperthermia was the very first oncotherapy in human medicine, but
its applicability in modern oncology was dubious. The discovery of electromagnetism
gave new hope a century ago, however, until up to now, it has been suffering from lack
of wide acceptance. Oncological hyperthermia suffers from multiple
unsolved medical and technical problems. The accurate selection of malignant
tissue and its proper heating in depth are real challenges together with the control and repeatability of the treatments. However, the
center of the problems is not technical: the living system tries to keep its
homeostatic equilibrium and creates active feedback mechanisms to eliminate or
at least correct the constrain heating in depth. The proper reaction on the
“gage of battle” has to involve the physiology, handle it complexly together
with bioelectromagnetism and update connected technology. The solution has to
be the integration of the natural bio-effects into the technological
constrains, acting in synergy with the physiological feedback mechanisms, and without
forcing effects out of the homeostatic control. The solution lies in strict
selection and adequate action in nanoscopic range, without exciting the robust
transport-mechanisms to operate against the energy delivery to the tumor.
Together with the local optimization, the systemic effects have to be considered,
because malignancy is not a local disease. This concept needs interactions with
the immune-system being effective on the disseminated cell in far distance too.
Our objective is to present a complex technical solution to this complex
problem.