Article citationsMore>>

Chu, G.C., Dunn, N.R., Anderson, D.C., et al. (2004) Differential requirements for Smad4 in TGFB-dependent patterning of the early mouse embryo. Development, 131, 3501-3512. http://dx.doi.org/10.1242/dev.01248

has been cited by the following article:

• TITLE: Utility of adeno-associated viruses to target members of the TGF-β superfamily in prostate cancer therapy

  AUTHORS: Priya Ramarao, Elspeth Gold

  KEYWORDS: AAV; Prostate Cancer; TGF-β Superfamily

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.4 No.10C, October 18, 2013

  ABSTRACT: Components of the TGF-β superfamily have been well established in their intricate and multifaceted roles in cancer progression and survival. The TGF-βs have been targeted therapeutically in an attempt to modify complex tumour networks to favour cancer cell destruction. Goals of these therapies are often to attack the “hallmarks” of cancer: characteristics acquired by cancer cells via re-wiring or manipulating existing biological pathways to their survival advantage. Of the multitude of targeted therapies currently available, viral therapies have shown much promise in their efficacy of treatment. This review highlights current viral therapies targeting members of the TGF-β superfamily, with a focus on the strengths and limitations associated with this form of targeted cancer therapy.