Article citationsMore>>

D. E. Discher, P. Janmey and Y. L. Wang, “Tissue Cells Feel and Respond to the Stiffness of Their Substrate,” Science, Vol. 310, No. 5751, 2005, pp. 1139-1143. http://dx.doi.org/10.1126/science.1116995

has been cited by the following article:

• TITLE: Modeling the Impact of Cell Type and Substrate Stiffness on Cell Traction

  AUTHORS: Srikanth Raghavan, Aravind R. Rammohan, Martial Hervy

  KEYWORDS: Cell-Matrix Adhesion; Extracellular Matrix; Polyacrylamide Gels; Elasticity Theory; Mechanotransduction; Stem Cell; Modeling

  JOURNAL NAME: Open Journal of Biophysics, Vol.3 No.4, October 17, 2013

  ABSTRACT: We propose a mathematical model to suggest a unified explanation behind the observation that some cell types tend to spread more efficiently on stiff substrates and are able to adapt their internal stiffness to the external stiffness. Our model also offers an explanation regarding the dependence of cell spreading on cell type. We show that our model for stiffness adaptation is in good agreement with experimental data. We also apply our model to calculate the energy of traction on bulk substrates as well as thin coatings, thereby extracting estimates of critical coating thickness as a function of cell type and coating bulk modulus.