TITLE:
Multifaceted role of TNF-α during the pathogenesis of rheumatoid arthritis
AUTHORS:
Ramanjaneya V. R. Mula, Rangaiah Shashidharamurthy
KEYWORDS:
Cytokines; Tumor Necrosis Factor-α; Rheumatoid Arthritis; Inflammation
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.10,
October
16,
2013
ABSTRACT: Tumor necrosis factor alpha (TNF-α) a cytokine has been shown to be the
key player during the pathogenesis of several autoimmune inflammatory disorders (presumably sterile inflammation) including
rheumatoid arthritis (RA). Several studies have shown that TNF-α is mainly involved in the proinflammatory responses. However recent studies have reported multifunctional role of
TNF-α during the development of RA.
Therefore, in this article we have highlighted the distinct functions of TNF-α during pathogenesis of RA.