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Kemppainen, E.A., Hedstrom, J.I., Puolakkainen, P.A., Sainio, V.S., Haapiainen, R.K., Perhoniemi, V., Osman, S., Kivilaakso, E.O. and Stenman, U.H. (1997) Rapid measurement of urinary trypsinogen-2 as a screening test for acute pancreatitis. New England Journal of Medicine, 336, 1788-1793.
http://dx.doi.org/10.1056/NEJM199706193362504

has been cited by the following article:

• TITLE: Use of the urinary trypsinogen-2 dipstick test in early diagnosis of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP)

  AUTHORS: Hasan El-Garem, Enas Hamdy, Sherif Hamdy, Mohammad El-Sayed, Aisha Elsharkawy, Azmi Mohammed Saleh

  KEYWORDS: ERCP; Pancreatitis; Urinary Trypsinogen-2 Dipstick Test

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.3 No.6, October 15, 2013

  ABSTRACT: Background: Acute pancreatitis is one of the most serious complications of ERCP. Early diagnosis of post ERCP pancreatitis helps physicians to provide intensive care and possible medical treatment as early as possible. Trypsinogen-2 in urine is a good diagnostic and prognostic marker of acute pancreatitis. Objectives: To evaluate the diagnostic value of urinary trypsinogen-2 dipstick test for early diagnosis of post ERCP pancreatitis. Methods: A total of 37 patients with obstructive jaundice were tested with the urinary trypsinogen-2 dipstick test and serum levels of amylase and lipase before ERCP and 6 hours after ERCP. Results: Post ERCP pancreatitis was diagnosed in 6 (16%) of 37 patients. The sensitivity, specificity, positive predictive value and negative predictive value of urinary trypsinogen-2 dipstick test at 6 hours after ERCP were 100%, 97%, 86%, 100% respectively. At the cutoff level (130 U/L) for lipase, the positive predictive value and negative predictive value all were (100%), however, the positive predictive value and negative predictive value for amylase levels at cutoff (122 U/L) were 60%, 100% respectively. Serum lipase level was the best test for diagnosing post ERCP pancreatitis followed by the urinary trypsinogen-2 dipstick test. Conclusions: The urinary trypsinogen-2 dipstick test can be used as a rapid and easy test for early diagnosis of post ERCP pancreatitis with high sensitivity and specificity.