TITLE:
Upon the Delivery Properties of a Polymeric System Based on Poly(2-Hydroxyethyl Methacrylate) Prepared with Protective Colloids
AUTHORS:
Loredana E. Nita, Aurica P. Chiriac, Manuela Nistor, Tatiana Budtova
KEYWORDS:
Biocompatible Polymers; Polymer Network; β Cyclodextrin; Poly(Aspartic Acid)
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.4 No.4,
October
10,
2013
ABSTRACT: A comparative study related to the preparation of
poly(2-hydroxyethyl methacrylate) (pHEMA) through radical polymerization
process in the presence of three different protective colloid substances,
respectively poly(vinyl alcohol) (PVA), β-cyclodextrin, or poly(aspartic acid)
(PAS), is presented. The
dependence of the thermal behavior of the polymers as well as their
morphological aspect, on the protective colloids used in synthesis was evidenced by polymers characterization. It is also demonstrated that
the swelling capacity is dependent on the protective colloid variant present
during the pHEMA preparation. This behavior induces as well interdependence on
the ability to load bioactive compounds onto the polymeric matrices. The distribution of the indomethacin (INN),
as model drug, into the pHEMA
network was put into evidence by near infrared chemical imaging (NIR-CI), a non-destructive technique and with its correspondingly statistical
analysis.