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Valgimigli, M., Malagutti, P., Aoki, J., Garcia-Garcia, H.M., Rodriguez Granillo, G.A., vanMieghem, C.A.G., Ligthart, J.M., Ong, A.T.L., Sianos, G., Regar, E., Van Domburg, R.T., De Feyter, P., de Jaegere, P. and Serruys, P.W. (2006) Sirolimus-eluting versus paclitaxel-eluting stent implantation for the percutaneous treatment of left main coronary artery disease: A combined RESEARCH and T-SEARCH long-term analysis. Journal of the American College of Cardiology, 47, 507-514. http://dx.doi.org/10.1016/j.jacc.2005.09.040

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• TITLE: Percutaneous treatment of de novo unprotected left main stenosis in unselected consecutive patients: Experience of a high volume center

  AUTHORS: Elisabetta Varani, Sabine Vecchio, Matteo Aquilina, Giuseppe Vecchi, Marco Balducelli, Valeria Frassineti, Massimo Margheri

  KEYWORDS: Unprotected Left Main; Percutaneous Coronary Intervention

  JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.3 No.7, October 9, 2013

  ABSTRACT: Background: Percutaneous coronary intervention (PCI) has been increasingly employed to treat unprotected left main (ULM) stenosis, with hard endpoints similar to by-pass surgery, in patients selected by a Heart Team. Methods: From January 2008 to December 2011, 317 unselected and consecutive patients with de novo ULM stenosis underwent PCI with both bare metal (BMS) and drug-eluting (DES) stents. Major adverse cardiovascular events, target lesion (TLR) and vessel (TVR) revascularization were evaluated over a mean period of 590 ± 371 days. Results: Our population was characterized by a mean age 72 ± 10 years, high rate of acute coronary syndrome (ACS) (either with ST or non-ST elevation myocardial infarction, 15.5% and 35% respectively), severe comorbidity 16%, mean Euroscore 7 ± 3, mean Syntax Score 25 ± 9. In-hospital mortality was 6%. During the follow-up period, all-cause mortality was 16.7%, falling to 7% at the end of the follow-up, excluding patients presenting with ACS. TLR was observed and treated in 15% of patients. BMS utilization, age >75 years, ACS indication, Syntax Score >32 and associated peripheral artery disease were independent predictors of mortality at multivariate analysis. Conclusions: Stenting of ULM stenosis appears to be associated with a favorable mid-term outcome, even in an unselected population.