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Sahuquillo, J., Rubio, E., Codina, A., Molins, A., Guitart, J.M., Poca, M.A., et al. (1991) Reappraisal of the intracranial pressure and cerebrospinal fluid dynamics in patients with the so-called “normal pressure hydrocephalus” syndrome. Acta Neurochirurgica (Wien), 112, 50-61. doi:10.1007/BF01402454

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• TITLE: Hakim-Adams syndrome secondary to syphilis

  AUTHORS: Ricardo Krause Martinez de Souza, Alexandre Zatera, Fernanda Leal Suzano, Flávia de Oliveira Braga, Samanta Fabrício Blattes da Rocha, Ricardo Ramina, Pedro André Kowacs

  KEYWORDS: Neurosyphilis; Hakim-Adams Syndrome; Syphilis; Normal Pressure Hydrocephalus

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.2 No.6, September 24, 2013

  ABSTRACT: Normal pressure hydrocephalus (NPH) secondary to syphilis is an atypical form of neurosyphilis with an unusual clinical presentation and uncommon neuroimaging findings. A case of Syndrome de Hakim-Adams occurring in a 79-year-old male was admitted for investigation of a dementia syndrome. The patient presented with clinical features and neuroimaging compatible with NPH. Syphilis serology was reactive and compatible with active disease. The patient was treated with crystalline penicillin (4 million units every 4 hours for 21 days) and was assessed again after three months, when his cognition and gait had improved and the urinary incontinence had resolved. According to this information, we describe a case of syphilis mimicking normal pressure hydrocephalus, making clear the importance of the investigation of sexually transmitted diseases in the differential diagnosis of dementia, even in patients without established risk supposedly.