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Y. Iwamoto, F. A. Robey, J. Graf, M. Sasaki, H. K. Kleinman, Y. Yamada and G. R. Martin, “YIGSR, a Synthetic Lamininpentapeptide, Inhibits Experimental Metastasis Formation,” Science, Vol. 238, No. 4830, 1987, pp. 1132-1134.

has been cited by the following article:

• TITLE: Molecular Modeling of Cell Adhesion Peptides on Hydroxyapatite and TiO2 Surfaces: Implication in Biomedical Implant Devices

  AUTHORS: Subhashis Biswas, Udo Becker

  KEYWORDS: Hydroxyapatite; Nanobiomaterial; Bone-Tissue Engineering; RGD; TiO2

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.4 No.4, September 23, 2013

  ABSTRACT: Molecular modeling as a tool in studying peptide-substrate interactions provides insight on peptide adsorption conformation, adsorption energy, and stability of the peptide-inorganic interface. This work investigates the hydration and interaction of cell-adhesion peptides, specifically RGD and YIGSR, with the hydroxyapatite surface and TiO2 surface in cluster and periodic boundary condition approaches. The comparison of adsorption energies of RGD and YIGSR on both Hydroxyapatite (HA) and TiO2 surfaces reveals the similarities in adsorption energy and orientation pattern of peptides on both surfaces. The models demonstrate that initial peptide orientation affects adsorption energy for both. YIGSR is consistently more strongly adsorbed to HA-(001) surfaces and steps than RGD for both the surfaces. In addition, RGD maintained its “hairpin”-like structure during adsorption on a flat HA-(001) surface, and a slightly “relaxed hairpin” structure on TiO2 (110) surface. Adsorption energies of RGD on TiO2 (110) surface are significantly more favorable compared to HA-(001) surface, suggesting potential role of TiO2 as biomedical implants when tissue regeneration occurs via cell signaling.