TITLE:
Recovery of nigrostriatal dopaminergic system insufficiency by allotransplantation of embryonic brain tissue
AUTHORS:
Olga Berchenko, Yelena Usmentseva
KEYWORDS:
Movement Violations; Catecholamines; Allotransplantation; Embryonic Tissue
JOURNAL NAME:
World Journal of Neuroscience,
Vol.3 No.4,
September
18,
2013
ABSTRACT: In an experiment in rats with
electrolytic lesion of the compact part of substantia nigra (SN) and after allotransplantation
of the embryonic tissue of SN in the caudate nucleus the features of movement
and emotional behavior in the Open Field Test (OFT), the rotation movements
caused by an administration of amphetamine, a content of catecholamines in the
caudate nucleus, hypothalamus and blood plasma have been investigated. It is
shown that the electrolytic lesion causes violations of the statokinetic reflexes,
the horizontal and the vertical movement activity, enhances the rotatory
behavior, slow the orienttate-searching and the emotional reactions that combined
with disbalance in dopamine-and noradrenalinetransmitter systems functioning.
Allotransplantation of the embryonic dofaminsynthesizing brain tissue
contributes to the restoration of movement activeity and its specific
neurotransmitter ensuring.