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Pena, A.M., Fabre, A., Débarre, D., Marchal-Somme, J., Crestani, B., Martin, J.L., Beaurepaire, E. and Schanne-Klein, M.C. (2007) Three-dimensional investigation and scoring of extracellular matrix remodeling during lung fibrosis using multiphoton microscopy. Microscopy Research and Technique, 70, 162-170. doi:10.1002/jemt.20400

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• TITLE: Analysis for stress environment in the alveolar sac model

  AUTHORS: Ramana M. Pidaparti, Matthew Burnette, Rebecca L. Heise, Angela Reynolds

  KEYWORDS: Alveolar Sac; Stress; Analysis; Modeling

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.9, September 20, 2013

  ABSTRACT: Better understanding of alveolar mechanics is very important in order to avoid lung injuries for patients undergoing mechanical ventilation for treatment of respiratory problems. The objective of this study was to investigate the alveolar mechanics for two different alveolar sac models, one based on actual geometry and the other an idealized spherical geometry using coupled fluid-solid computational analysis. Both the models were analyzed through coupled fluid-solid analysis to estimate the parameters such as pressures/ velocities and displacements/stresses under mechanical ventilation conditions. The results obtained from the fluid analysis indicate that both the alveolar geometries give similar results for pressures and velocities. However, the results obtained from coupled fluid-solid analysis indicate that the actual alveolar geometry results in smaller displacements in comparison to a spherical alveolar model. This trend is also true for stress/strain between the two models. The results presented indicate that alveolar geometry greatly affects the pressure/velocities as well as displacements and stresses/strains.