TITLE:
Assessment of Secondary Metabolites from Marine-Derived Fungi as Antioxidant
AUTHORS:
Nihad Abdel-Monem, Ahmed M. Abdel-Azeem, E. S. H. El Ashry, Doaa A. Ghareeb, Asmaa Nabil-Adam
KEYWORDS:
DPPH; TBARS; Marine Drugs; Marine Derived Fungi; Anti-Inflammatory; Antioxidant Capacity
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.3 No.3,
September
20,
2013
ABSTRACT: Marine derived fungi are considered as a promising
source of novel drugs due to their biodiversity and consequent chemo-diversity.
Although marine microorganisms especially fungi are not well defined
taxonomically, making this a promising frontier for the discovery of new medicines. This
study focused on marine derived fungi as a model for bioactive exploration for
new entities with anti-inflammatory and antioxidant capacity. Three in-vitro assays were used to investigate
the bioactive antioxidant potentiality of fungal extracts. Thiobarbituric acid
(TBARS),α,α-Diphenyl-β- picrylhydrazyl
(DPPH) and NO assay are based on their
total phenolic and flavonoid content of each extract group. Ch. globosum
recorded the highest antioxidant activity (92.82%) in TBARS assay, while G. dankaliensis came first by recording
59.28% in DPPH assay in comparison with ascorbic acid (61.83%). In NO
inhibition assay, N. oryzae showed
49.3% comparing with ascorbic acid (73.12%). From the
preliminary result of our extracts, we can consider the marine derived fungi
extracts as promising antioxidant and anti-inflammatory drug candidate.