TITLE:
Immune mechanisms of ischemia-reperfusion injury in transplantation
AUTHORS:
Saami Khalifian, Justin M. Broyles, Sami H. Tuffaha, Mohammed Alrakan, Zuhaib Ibrahim, Karim A. Sarhane
KEYWORDS:
Ischemia-Reperfusion; Reactive Oxygen Species; Allograft Damage; Solid Organ Transplantation; Immune Mechanisms
JOURNAL NAME:
Open Journal of Immunology,
Vol.3 No.3,
September
20,
2013
ABSTRACT: All allografts suffer a number of unavoidable ischemic insults. These, starting with brain death and ending with reperfusion, are very troublesome, as ischemia-reperfusion
injury (IRI) is demonstrated to be a major cause of allograft damage in various
types of transplantations. To counter the threat this poses to allograft function,
investigators have worked diligently over the past decades in clinical settings
and in the laboratory to understand the pathophysiology and immune mechanism
underlying IRI hoping to ultimately devise strategies that lessen its
detrimental effects on allografts. Herein, we review the major immune components
of the IRI dynamic process. Better understanding of the cellular
pathophysiological processes underlying IRI will hopefully result in the design
of more targeted therapies to prevent the injury, hasten repair, and minimize
chronic progressive allograft damage.