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Takahashi, Y., Ishii, Y., Nishida, Y., et al. (2006) Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH. Cancer Genetics and Cytogenetics, 168, 30-35. doi:10.1016/j.cancergencyto.2005.12.011

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• TITLE: Ubiquitin-conjugating enzyme involved in the immune response caused by pathogens invasion

  AUTHORS: Liang Chen, Chen Cheng, Chunxia Zhang, Qin Yao, Ermi Zhao

  KEYWORDS: Ubiquitin-Conjugating Enzyme; Ubiquitin-Proteasome Pathway; Pathogen; Immune Response

  JOURNAL NAME: Open Journal of Immunology, Vol.3 No.3, September 18, 2013

  ABSTRACT: Ubiquitin-proteasome pathway (UPP) is a significant way of protein degradation and modification in eukaryotic cell and involved in a complex series of intracellular processes. As a key component in UPP,ubiquitin-conjugating enzyme (E2) plays an extremely important role in ubiquitin (Ub) transferring and substrate specific recognition. Abundant evidences have proved that UPP is involved in cells immune reaction caused by pathogens and the attendance of E2 has a significant effect on host cells and pathogen. This article presents an overview of the current research on E2s that is involved in immune response caused by viruses and bacteria.