TITLE:
Ubiquitin-conjugating enzyme involved in the immune response caused by pathogens invasion
AUTHORS:
Liang Chen, Chen Cheng, Chunxia Zhang, Qin Yao, Ermi Zhao
KEYWORDS:
Ubiquitin-Conjugating Enzyme; Ubiquitin-Proteasome Pathway; Pathogen; Immune Response
JOURNAL NAME:
Open Journal of Immunology,
Vol.3 No.3,
September
18,
2013
ABSTRACT: Ubiquitin-proteasome
pathway (UPP) is a significant
way of protein degradation and modification in eukaryotic cell and involved in
a complex series of intracellular processes. As a key component in UPP,ubiquitin-conjugating enzyme (E2) plays an extremely
important role in ubiquitin (Ub) transferring and substrate specific
recognition. Abundant evidences have proved that UPP is involved in cells
immune reaction caused by pathogens and the attendance of E2 has a significant
effect on host cells and pathogen. This article presents an overview of the
current research on E2s that is involved in immune response caused by viruses
and bacteria.