TITLE:
Inflammatory Biomarkers in Asian Indian Women with Metabolic Syndrome
AUTHORS:
Pooja R. Singhania, Garima Gupta, Kasturi Sen Ray
KEYWORDS:
Metabolic Disorder; Inflammatory Biomarkers; Homocysteine; C-Reactive Protein; Asian Indians; Metabolic Syndrome
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.4 No.10,
September
17,
2013
ABSTRACT: Cardiovascular diseases (CVD) are the leading cause of mortality necessitating its early detection. The emergence of newer subclinical biomarkers in addition to the known cardiometabolic risk factors may play an important role in early detection of CVD risk. In the present study, 74 adult females (30 -75 y) with metabolic syndrome (MS) were selected and additional biochemical parameters such as C-reactive protein (CRP) and Homocysteine (Hcy) levels were analyzed. The average body mass index (BMI) and waist circumference of subjects were found to be 30 kg/m2 and99 cmrespectively. Mean LDL levels were found to be much higher than normal (139 mg/dl) while the HDL levels were low (41.5 mg/dl). The average fasting blood sugar and insulin levels were within the normal range. However, 40.5% females had serum Hcy levels >13.2 μmol/l and 59.5% women had CRP levels >3 mg/L indicating increased risk of CVD. Higher Hcy levels were associated with hyperinsulinemia (p